Aconitine and its related alkaloids are known cardiotoxins with no therapeutic role in modern western medicine. The rootstocks of Aconitum plants, which contain aconite alkaloids, have been common components of Chinese herbal recipes. We have documented life-threatening intoxication in 17 Chinese subjects after accidental herb-induced aconite poisoning. All patients developed symptoms of aconit...

The effect of grayanotoxin I (GTX I), veratridine and aconitine with either an external or internal concentration of 100 microM on L-type calcium (Ca) channels was studied using the whole cell patch clamp and internal dialysis methods. The experimental conditions for the modification of sodium (Na) channels induced by the internal application of these toxins was determined by showing sustained ...

A new aconitine-type norditerpenoid alkaloid, kohatenine (1) [10β-hydroxy-1α,8β,16β-trimethoxy6α,14α-diacetyl-N-ethyl aconitane], along with four known alkaloids, condelphine (2), talatisamine (3), peregrine (4), and 14-O-acetyltalatisamine (5), was isolated from the aerial parts of Delphinium kohatense Munz. The structure of the new compound was deduced on the basis of combined MS (EI and FAB)...

Conflicts of interest: No potential conflicts of interests are declared. of the crude drug Fu Zi, otherwise known as RadixAconiti Lateralis Praeparata (1). It contains aconitine-type alkaloids, and has been used to alleviate severe pain and to treat rheumatic diseases from ancient times (2). Many aconite poisoning cases have been reported, most resulting fromoraluse, producing systemic symptoms...

The ancolies are regarded as dangerous (seeds). The alkaloids which they contain bring closer aconitine but their toxicity is definitely less. Their extreme acridness generally avoids poisonings. The plant’s seeds and roots are highly poisonous however, and contain cardiogenic toxins which cause both severe gastroenteritis and heart palpitations if consumed as food. Folk medicine used very smal...

α-Cyano-4-hydroxycinnamic acid (CHCA), an organic matrix molecule for matrix-assisted laser desorption/ionization mass spectrometry, was adsorbed to NH4 (+)-type zeolite surface, and this new matrix was used for the detection of low-molecular-weight compounds. It was found that this matrix could simplify the mass spectrum in the low-molecular-weight region and prevent interference from fragment...

background there is the controversy concerning the main component of tobacco, which is responsible for its arrhythmogenesis. in addition, there is the lack of adequate information about the influence of combination of black tea and nicotine on heart rhythm. objectives this study aimed to examine whether pretreatment with black tea and nicotine could modulate the susceptibility to lethal ventric...

Four neurotoxins that activate the action potential Na+ ionophore of electrically excitable neuroblastoma cells interact with two distinct classes of sites, one specific for the alkaloids veratridine, batrachotoxin, and aconitine, and the second specific for scorpion toxin. Positive heterotropic cooperativity is observed between toxins bound at these two classes of sites. Tetrodotoxin is a nonc...

Tibetan ethnomedicine is famous worldwide, both for its high effectiveness and unique cultural background. Many poisonous plants have been widely used to treat disorders in the Tibetan medicinal system. In the present review article, some representative poisonous plant species are introduced in terms of their significance in traditional Tibetan medicinal practices. They are Aconitum pendulum, S...