BACKGROUND Coagulopathy is an important contributor to morbidity and mortality in trauma patients. Acidosis contributes to coagulopathy. Acidosis can be neutralized with intravascular bicarbonate, but it is unclear if the coagulation defect is rapidly reversed. The effects of acidosis and bicarbonate neutralization on coagulation function were investigated in vivo. METHODS Acidosis was induce...

BACKGROUND The effects of acute respiratory versus metabolic acidosis on the myocardium and their consequences on adrenoceptor stimulation remain poorly described. We compared the effects of metabolic and respiratory acidosis on inotropy and lusitropy in rat myocardium and their effects on the responses to α- and β-adrenoceptor stimulations. METHODS The effects of acute respiratory and metabo...

The fetus depends on the mother for placental exchange of oxygen and carbon dioxide. This in turn relies on adequate maternal blood gas concentrations, uterine blood supply, placental transfer and fetal gas transport. Disruption of any of these can cause fetal hypoxia, which, despite compensatory mechanisms, may lead to acidosis. When severe and acute (lasting hours), but especially if prolonge...

OBJECTIVES Cardiovascular disease causes a major clinical problem in patients with end stage renal disease. Since metabolic acidosis is very common in patients with end stage renal disease, we aimed to investigate the effect of experimentally-induced metabolic acidosis on serum lipid profile and aortic fatty streak (FS) formation in normal and high-cholesterol fed rabbits. MATERIALS AND METHO...

The mammalian proximal tubule is an important mediator of the renal adaptive response to systemic acidosis. In chronic metabolic and respiratory acidosis the bicarbonate reabsorptive (or proton secretory) capacity is increased. This increase is mediated, at least in part, by an increase in Vmax of the luminal Na/H antiporter. To determine whether this adaptation involves increased mRNA expressi...

KONTOS, HERMES A., DAVID W. RICHARDSON, AND JOHN L. PATTERSON, JR. Roles of hypercapniu and acidosis in the vasodilutor response to hyperc@c acidosis. Am. J. Physiol. 2 15 (6) : 1406-1408. 1968.-The importance of increased Pcoz and decreased pH in the mediation of the effects of hypercapnic acidosis on heart rate, blood pressure, and blood flow and vascular resistance of the human forearm were ...

results fifty-seven patients were enrolled; 35 patients (62.5 %) were male. the mean of etco2 and paco2 of patients were 41.49 ± 9.80 and 64.74 ± 9.76, respectively. the mean of paco2 was significantly more than the means of etco2 in patients with copd. the association between arterial bicarbonate and etco2 was weak and not significant (p = 0.136 and r = 0.04). conclusions capnography can be us...

A case of renal tubular acidosis (RTA) who had gradual onset of paralysis of lower extremities and persisted for a long time is presented. His primary workups were mistaken for muscular dystrophy. Eventually, an abdominal ultrasonography revealed small stones in both of the kidneys and his workup for the stones were in favor of distal renal tubular acidosis and advanced rickets with hypokal...

Robergs, Robert A., Farzenah Ghiasvand, and Daryl Parker. Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 287: R502–R516, 2004; 10.1152/ajpregu.00114.2004.—The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt s...

Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer cells in response to three distinct tumor microenvironmental stresses: lactic acidosis, glucose deprivation, and hypoxia. We found that lactic...