A patient with early achalasia presented spontaneous strong rhythmic non-propulsive contractions at ~7/min, independent of swallows. Our aim was to evaluate characteristics of the rhythmic contractions, provide data on the structure of pacemaker cells in the esophagus and discuss a potential role for interstitial cells of Cajal (ICC) in the origin of rhythmicity. We hypothesize that intramuscul...

Aim The aim of this study was to evaluate and compare the functional results before and after laparoscopic Heller myotomy for Iranian patients with achalasia. Background Achalasia is a severe neuromuscular disorder of the esophagus, characterized by the loss of peristalsis and an inability of the lower esophageal sphincter (LES) to reach optimal relaxation. Methods In this cross sectional s...

We have evaluated esophageal tone in two different conditions that, in some cases, similarly impair phasic esophageal motility. Studies were performed in 14 healthy volunteers, 10 patients with total esophageal aperistalsis secondary to gastroesophageal reflux disease (GERD), and 25 untreated achalasia patients. We quantified esophageal compliance and relaxation induced by a nitric oxide donor ...

AIM To compare expression of Ca(2+)-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS Sarcoplasmic reticulum Ca(2+) ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats...

A case of endoscopically resected early esophageal carcinoma associated with achalasia is reported. A 63-year-old woman was made diagnosis of esophageal achalasia, sigmoid type and grade III. The patient was operated by Tokai University method, Heller's long esophagomyectomy, Hill's posterior cardiopexy, fundoplication and selective proximal vagotomy using a laparotomy. Two years and six months...

Introduction: Achalasia occurs in up to 10 out of every 100,000 people worldwide, is associated with a large number symptoms that can impact the patient's quality life; laparoscopic myotomy Héller fundoplication represents gold standard surgery treatment this condition, has shown symptomatic improvement patient, However, studies have reported there are no significant manometric and changes post...

Achalasia is a rare esophageal motility disorder defined as impaired relaxation of the esophagogastric junction (EGJ) and the absence of esophageal peristaltic contractions. High resolution manometry (HRM) is now the gold standard for the diagnosis of achalasia. Pandolfino et al. proposed classifying achalasia into three subtypes based on esophageal contraction patterns on HRM [1]. In the most ...

chronic inflammatory demyelinating polyneuroradiculopathy (cidp) is an immune mediated disorder characterized by progressive developing or relapsing symmetrical motor or sensory symptoms in more than one limb over a period of two months. achalasia, as a primary esophageal motility disorder, is also characterized by increasing the tone of lower esophageal sphincter, absence or incomplete sphinct...

THE essential disturbance in achalasia is a failure of the cardiac sphincter to relax adequately when the patient swallows. This causes the oesophageal tube to be closed to both liquids and solids by an elastic process that can be forced open a varying amount by building up pressure in the oesophagus, in addition there is damage to some of the postganglionic neurones in the wall of the oesophag...

AIM To assess reference values in the literature for esophageal distensibility and cross-sectional area in healthy and diseased subjects measured by the functional lumen imaging probe (FLIP). METHODS Systematic search and review of articles in Medline and Embase pertaining to the use of FLIP in the esophagus was conducted in accordance with the PRISMA guidelines. Cross-sectional area and dist...