The YT blood group antigen is located on human red blood cell (RBC) acetylcholinesterase. Wild-type acetylcholinesterase, YT1, has histidine at codon 322, whereas the genetic variant of acetylcholinesterase, YT2, has asparagine. This mutation is located within exon 2 of the ACHE gene, an exon that is present in all alternatively spliced forms of acetylcholinesterase. Therefore, acetylcholineste...

We previously reported that acetylcholinesterase plays a critical role in apoptosis and its expression is regulated by Ca(2+) mobilization. In the present study, we show that activated calpain, a cytosolic calcium-activated cysteine protease, and calcineurin, a calcium-dependent protein phosphatase, regulate acetylcholinesterase expression during A23187-induced apoptosis. The calpain inhibitor,...

CONTEXT A central tenet of Alzheimer disease (AD) is the loss of cortical cholinergic function and cholinergic markers in postmortem brain specimens. Whether these profound deficits in cholinergic markers found in end-stage patients are also found in patients with much earlier disease is not known. OBJECTIVE To determine whether cholinergic deficits in AD precede, follow, or occur in synchron...

Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. It is a highly conserved molecule, and only a few naturally occurring genetic polymorphisms have been reported in the human gene. The goal of the present study was to make a systematic effort to identify natural single nucleotid...

Absence [ZBK06]. Absorbers [MS08]. Accelerated [AVE08, AL14, CWD08]. Account [SSJ12]. Accounting [BFRD13]. Accuracy [Aar04, Str05, VO13, VVVR07]. Accurate [ACHR06, CTL16, CR06]. Acoustic [BIT10, CS14, HMS14, LLZ14, LR10a, VMK05]. Across [AD16, Fan09, Rob09]. Active [HL10a]. Activities [LYTP13]. Activity [BRR13, GSF09]. Adaptive [AE06, AB15a, BCK05, CDG14, EGM13, FYW11, HOS14, JLT04, KJ16, KN06,...

The treatment of the Charles Bonnet syndrome (CBS) can become extremely complex and must include all areas related to its etiopathogeny. Some aspects of the comprehensive treatment of the process include providing adequate information to the patient and his family, improving their quality of life, treating the cause whenever possible or the secondary anxiety syndrome.1,2 In what concerns the me...

background: galantamine is a drug used for the treatment of alzheimer’s disease and some other cognitive disorders. it is an inhibitor of acetylcholinesterase however, interaction with nicotinic acetylcholine receptors has also been reported. owing to the significant role of cholinergic anti-inflammatory pathways in neuro-immunomodulation, we decided to examine the effect of galantamine on tula...

The distribution of acetylcholinesterase in the canine kidney was studied by the histochemical method of Karnovsky and Roots and compared to the distribution of adrenergic fibers studied with the fluorescence histochemical method of Falck and Hillarp. Specific inhibitors of nonspecific cholinesterase and acetylcholinesterase were used to differentiate between the two enzymes. In the hilus, acet...

Ipidacrine (NIK-247, 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline monohydrochloride monohydrate) is a novel substance synthesized by the National Research Center for Biologically Active Compounds in the Russian Federation. Ipidacrine was earlier referred to by the chemical name amiridine (7). This compound contains the structure of 4-aminopyridine and is structurally very similar to ...