In the present study, a series of 2-substituted-pyridines were synthesized and characterized by IR, (1)H-NMR and Elemental Analysis. The compounds were assayed against seizures induced by maximal electro shock (MES) and pentylenetetrazole (scMet). Neurologic deficit was evaluated by the rotarod test. The decrease in the elevated motor activity by introceptive chemical stimuli (amphetamine antag...

The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and hodgkin’s disease. it requires initial activation in liver through an n-demethylationreaction. the active metabolite prevents the progress of disease via alkylation of guanine bases in dna strands. in order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

background: organophosphorus (op) poisoning is a major public health problem in developing world. op pesticides inhibit carboxylic esterase enzymes including plasma cholinesterase (pche). clinical manifestations following op poisoning can be associated with the extent of decrease of pche. this study was designed to investigate the relevance of pche level to clinical manifestations in op poisoni...

we have recently synthesized [ni (map) ] complex [h-map= 2- (methylamino) pyridine]. 2- (methy1amino)pyridine reacts with meli in thf and generates the lithium salt (li-map). further reaction of nicl with two equivalent of this ligand in thf leads to the formation of a dark red solution. analytical data, molecular weight, and magnetic susceptibility of this complex confirm the formula [ni (map)...

A series of dimetallic and monometallic Cp*Ir(III) complexes bearing naphthalene-diimide-decorated N-heterocyclic carbene/pyridine [NDI-(NHC-pyridine)] ligands were prepared characterized. The show a C,C-chelating coordination the NHC-pyridine ligand, with pyridine ring ligand bound to metal via cyclometallation rather than by its nitrogen atom, although atom could be achieved subjecting one re...

1. Inhibition by pyridine of reduction of NAD by ethanol in the presence of yeast alcohol dehydrogenase was studied at 25 degrees in 60mm-glycine buffer (K(+), pH9.3). 2. The apparent Michaelis constant for ethanol increases linearly and that for NAD increases non-linearly with pyridine concentration. 3. Rates, v, observed in the presence of pyridine are lower than the values calculated from th...

Overview to Pyridine Nucleotides Review Series [Circ Res. 2012;111:604–610.] Regulation of Cell Survival and Death by Pyridine Nucleotides [Circ Res. 2012;111:611–627.] Pyridine Nucleotide Regulation of Cardiac Intermediary Metabolism [Circ Res. 2012;111:628–641.] Sirtuins and Pyridine Nucleotides [Circ Res. 2012;111:642–656.] Sirtuins and Pyridine Nucleotides [Circ Res. 2012;111:642-656.] Regu...