background:abortion is one of the most important factorsreducing lambing rate and consequently profitability of sheepfarms. in addition to financial losses, it is also important from azoonotic point of view. objectives: the aim of this study wasto investigate bacterial abortifacient agents in an outbreak ofabortion occurring in afshari sheep in the northwest of zanjanprovince. methods:vaginal s...

Trichosanthin (TCS), known as a plant toxin, is applied as a midterm abortifacient in clinics, and currently reported to exhibit other biological and pharmaceutical effects such as anti-tumor, anti-HIV, and Immunoregulation. TCS was found out to firmly inactivate the ribosomes of the eukaryotic cell, but this finding was far enough to explain its various biological and pharmaceutical effects. O...

Trichosanthin, an abortifacient, immunosuppressive and anti-tumor protein purified from the traditional Chinese herb medicine Tian Hua Fen, is a potent inhibitor against HIV-1 replication. Under normal enzymatic digestion conditions, trichosanthin cleaves the supercoiled double-stranded DNA to produce nicked circular and linear DNA. Trichosanthin has no effect on linear double-stranded DNA. Nei...

Misoprostol is a synthetic prostaglandin E1 analogue approved by the Food and Drug Administration (FDA) for the prevention and treatment of gastroduodenal ulcers. Norman et al. first demonstrated its uterocontractive abortifacient properties in 19911. This publication generated great interest in the search for the potential uses of misoprostol in Obstetrics and Gynecology. Misoprostol has since...

Background and Purpose: Euphorbia heterophylla Linn. (Euphorbiaceae) is a promising medicinal plant used as an oxytocic in folkloric medicine. The study investigated the uterotonic abortifacient effects of aqueous leaf extract (AEEH). 
 Methods: GC-MS analysis AEEH was done. In vitro experiment on contractile activity conducted uterus nulliparous female Sprague Dawley rats using isolated o...

Traditional remedies are part of the cultural and religious life of the African people. In this manuscript the nature and range of traditional remedies used for female complaints in relation to gynaecological conditions and disorders is reviewed. A total of 156 medicinal plant species are documented as being used for gynaecological complaints in South Africa. These are presented in a table with...

The configurational and conformational analyses of α-methylene-γ-butyro steroidal spirolactones have been accomplished using 2D COSY, NOESY, ROESY and HETEROCOSY in conjunction with 1D H NMR. The analyses indicate that the major or the only spirolactones formed at positions 2, 3 and 6 of the steroids have the steroidal ring bearing the spirolactone in a chair conformation with an axial disposit...

The objectives of this study were to determine the effectiveness, side effects, and acceptability of one-third the standard 600 mg dose of mifepristone (200 mg) to induce abortion. A prospective trial at seven sites enrolled women > or = 18 years, up to 8 weeks pregnant, and wanting an abortion. The women received 200 mg mifepristone orally, self-administered 800 micrograms misoprostol vaginall...