نتایج جستجو برای: abcg1 protein
تعداد نتایج: 1235025 فیلتر نتایج به سال:
BACKGROUND Epigenetic mechanisms might be involved in the regulation of interindividual lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this study was to investigate the association between genome-wide DNA methylation and blood lipid levels high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and total cholester...
هدف از این مطالعه بررسی شش هفته تمرین هوازی با و بدون عصاره بنه (4 هفته، 1 میلی گرم به ازای هر کیلوگرم وزن بدن) روی بیان ژن abcg1، abcg5، ویسفاتین و pyy(3-36) در موش های صحرایی ماده.20 سر موش ماده (6-8 هفته ای 128-158 گرمی) که به طور تصادفی به گروه سالین کنترل، سالین تمرین، بنه کنترل و بنه تمرین تقسیم شدند. گروه های تمرینی به مدت شش هفته (5 روز در هفته، به مدت 60 دقیقه و سرعت 25 متر بردقیقه با ...
We previously reported that cholesterol-enriched macrophages excrete cholesterol into the extracellular matrix. A monoclonal antibody that detects cholesterol microdomains labels the deposited extracellular particles. Macro-phage deposition of extracellular cholesterol depends, in part, on ABCG1, and this cholesterol can be mobilized by HDL components of the reverse cholesterol transport proces...
The gene that codes for the ABC transporter ABCG1 is located in a chromosomal susceptibility region (21q22.3) for affective disorders. Genetic variations in ABCG1 have been associated with affective disorders in Japanese males. In this study, we investigated the distribution of a G2457A polymorphism in patients with affective disorders, suicide attempters with various psychiatric diagnoses and ...
OBJECTIVE Liver X receptor (LXR) activators decrease atherosclerosis in mice. LXR activators (1) directly upregulate genes involved in reverse cholesterol transport and (2) exert anti-inflammatory effects mediated by transrepression of nuclear factor-κB target genes. We investigated whether myeloid cell deficiency of ATP-binding cassette transporters A1 and G1 (ABCA1/G1), principal targets of L...
Conjugated Linoleic Acids (CLAs) are minor components of the diet with many reported biological activities. Our aim was to examine the function of the single trans-9,trans-11 (t9,t11), cis-9,trans-11 (c9,t11), and trans-10,cis-12 (t10,c12) isomers on gene expression in human macrophages. Therefore we incubated in vitro MCSF differentiated monocyte derived macrophages from three healthy donors a...
Macrophages have the right tools to synthesize all the free cholesterol they need. If macrophages also could degrade cholesterol when they have too much, the concept of in vivo reverse cholesterol transport (RCT) would be irrelevant. Fortunately for those of us who do research in this area, the ability of macrophages to closely regulate their cellular cholesterol levels is accomplished not by c...
Members of the ATP-binding cassette (ABC) transporters play a pivotal role in cellular lipid efflux. To identify candidate cholesterol transporters implicated in lipid homeostasis and mammary gland (MG) physiology, we compared expression and localization of ABCA1, ABCG1, and ABCA7 and their regulatory genes in mammary tissues of different species during the pregnancy-lactation cycle. Murine and...
Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood. Mice deficient in the adenosine triphosphate-binding cassette (ABC) transporters ABCA1 and ABCG1, which promote cholesterol efflux from macrophages and suppress atherosclerosis in hypercholesterolemic mice, displayed leukocytosis, a trans...
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