Introduction and aim. The association between periodontitis (PD) rheumatoid arthritis (RA) has been analyzed described in literature. Periodontal pathogens, such as “Porphyromonas gingivalis” “Aggregatibacter actinomycetemcomitans” are pointed the common factors for both diseases. In this work we demonstrate that treatment of dental oral diseases is an unconditional requirement patients with RA...

A case of subacute bacterial endocarditis due to Actinobacillus actinomycetemcomitans is reported. The patient was successfully treated first by a combination of gentamicin and ampicillin and then, because of severe allergic reactions, ampicillin was replaced by co-trimoxazole; symptoms did not recur and blood cultures remained sterile. A synoptic table is presented of 19 reported cases of infe...

BACKGROUND: Search for new effective means of preventing inflammatory complications in the state peri-implant tissues is relevant; particular, products from coniferous greens produced by Solagift company (Tomsk) are interest. The bioeffective cell juice Siberian fir, 100% carbon dioxide extract fir (water fraction), stands out among them. Fir recommended enhancing immunity, diseases upper respi...

Periodontitis adalah peradangan pada jaringan pendukung gigi yang disebabkan oleh kelompokmikroorganisme tertentu salah satunya bakteri Aggregatibacter actinomycetemcomitans, yangmenyebabkan kerusakan ligamen periodontal dan tulang alveolar. Penelitian ini bertujuan untukmembuktikan apakah ekstrak teh putih efektif menghambat pembentukan biofilm bakteriAggregatibacter actinomycetemcomitans seca...

Extracts of certain strains of Actinobacillus actinomycetemcomitans are inhibitory to strains of Streptococcus sanguis such as S. sanguis ATCC 10556. The isolation of a protein from an A. actinomycetemcomitans sonic extract which copurified with the inhibitory activity was accomplished by preparative isoelectric focusing, Sephadex G-100 gel filtration chromatography, and preparative polyacrylam...

Infections caused by multiple organisms, or polymicrobial infections, are likely more common than is broadly appreciated. Interaction among microbial communities (and with their host) can change the infection landscape by subverting immunity, providing nutrients and inhibiting competing microbes. Stacy et al. (A. Stacy, D. Fleming, R. J. Lamont, K. P. Rumbaugh, and M. Whiteley, mBio 7:e00782-16...

Actinobacillus actinomycetemcomitans leukotoxin lysed human neutrophil cytoplasts. The reaction was associated with a rapid influx of extracellular calcium, a collapse in membrane potential, release of lactate dehydrogenase, and overt disintegration of the plasma membrane. These functional and structural alterations in the plasmalemma of neutrophil cytoplasts reinforce the hypothesis that A. ac...

Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other...

Directed mutagenesis of a gene coding for a membrane protein of the periodontopathogen Actinobacillus actinomycetemcomitans was achieved by conjugation. The gene was disrupted by insertion of an antibiotic cassette into a unique endonuclease restriction sequence engineered by inverse PCR. The disrupted gene was cloned into a conjugative plasmid and transferred from Escherichia coli to A. actino...