نتایج جستجو برای: 99mtc

تعداد نتایج: 4699  

2015
Bing Yan Fan Qiu Ling Ren Haojie Dai Wei Fang Haibo Zhu Feng Wang

99mTc-3P-RGD2 and SPECT/CT were valuable tools for selecting patient likely benefit from integrin αvβ3 blocking therapy. To evaluate the feasibility of 99mTc-3P-RGD2 imaging to detect head and neck squamous cell carcinoma, 99mTc-3P-RGD2 was prepared and the relationship between its accumulation and integrin αvβ3 expression in nude mice bearing HEP-2 or CNE-1 carcinoma xenograft were analyzed. T...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006
Dietmar Berndorff Sandra Borkowski Dieter Moosmayer Francesca Viti Beate Müller-Tiemann Stephanie Sieger Matthias Friebe Christoph S Hilger Luciano Zardi Dario Neri Ludger M Dinkelborg

UNLABELLED The aim of this study was to target the angiogenesis-associated extracellular matrix protein ED-B fibronectin for molecular imaging of solid tumors. Recombinant and chemically modified derivatives of the single-chain antibody fragment (scFv) L19, capable of being labeled with 99mTc, were synthesized and radiolabeled. The resulting compounds 99mTc-AP39, 99mTc-L19-His, and 99mTc-L19-Hi...

2016
Marija Darkovska-Serafimovska Emilija Janevik-Ivanovska Icko Djorgoski Zorica Arsova-Sarafinovska Milka Zdravkovska Trajan Balkanov Nenad Ugresic

AIM The aim of this study was to investigate the possibility of using 99mtechnetium (99mTc)-labeled tirofiban (a reversible antagonist of glycoprotein IIb/IIIa) for detection of deep venous thrombosis (DVT) in rats without causing an antiplatelet effect. METHODS The ability of in vitro tirofiban to inhibit adenosine 5'-diphosphate (ADP)-induced platelet aggregation was evaluated using optical...

Journal: :Cancer research 1998
I Virgolini M Leimer H Handmaker S Lastoria C Bischof P Muto T Pangerl D Gludovacz M Peck-Radosavljevic J Lister-James G Hamilton K Kaserer P Valent R Dean

Recent data suggest that somatostatin receptors (SSTRs) are expressed on various tumor cells. High-level expression of SSTR on the tumor cell surface provides the basis for the successful clinical use of radiolabeled ligands for the in vivo localization of tumor sites. We have characterized the in vitro binding properties of the novel SSTR ligand 99mTc-P829 using primary human tumors (carcinoid...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007
Preeti Misra Valerie Humblet Nadine Pannier Wolfgang Maison John V Frangioni

UNLABELLED Small-molecule ligands specific for prostate-specific membrane antigen (PSMA) have the potential to improve prostate cancer imaging. However, highly charged ligands are difficult to label with 99mTc and to purify. In this study, we present an adamantane-trimerized small molecule that has nanomolar binding to PSMA and also has 12 negative charges. METHODS To convert this molecule in...

2017
Xiao-Chun Zhu Kai Zhou Shi-Qing Xu Yu-Bo Ma

BACKGROUND The aim of this study was to evaluate the value of semiquantitative analysis (SQA) of 99mTc-MIBI imaging in predicting early-stage cervical lymph node metastasis (CLNM) in thyroid carcinoma (TC). MATERIAL AND METHODS TC patients (n =106) undergoing surgical resection and histopathological examination were enrolled. All patients received 99mTc-MIBI imaging prior to surgery. P-glycopro...

Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [99mTc(H2O)3(CO)3]+ complex. [99mTc]-ECB-DG and [99mTc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na99mTcO4 in 1 mL saline. Radi...

Journal: :Iranian South Medical Journal 2022

Evaluating the Effect of Injected Dose 99mTc- MIBI on Quantitative Parameters Myocardial Perfusion Imaging

Journal: :iranian journal of nuclear medicine 2012
cnb harisankar

parathyroid adenoma involving a single parathyroid gland is the underlying cause of 80-85% of primary hyperparathyroidism (phpt). skeletal system is significantly affected by phpt. brown tumors are known to have affinity for 99mtc-mibi. we report a rare case of phpt presenting with diffuse bony pain, high calcium level and significantly elevated alkaline phosphatase level. 99mtc-pertechnetate/9...

Journal: :Nuklearmedizin. Nuclear medicine 2009
Ramin Sadeghi Hamid Reza Kianifar Vahid Reza Kakhki Seyyed Rasoul Zakavi Kianoush Ansari

AIM Hepatobiliary scintigraphy is an integral part in the diagnostic work-up of the neonatal cholestasis syndrome. However, less than optimal specificity is its major disadvantage. Differentiation between biliary atresia and neonatal hepatitis is nearly impossible in some cases with poor hepatocellular function. 99mTc sestamibi (MIBI) is a cationic lipophilic agent which is a substrate of P-gly...

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