www.vi-vi.org We are only US$945 million short of successfully eradicating poliomyelitis: here, a case for why polio eradication should be made a priority worldwide is made – a proposal that is both economically viable and important for health care initiatives in the future. With only 128 cases reported in 2012 (by 6 September 2012) compared with 356 in 2011, we have come closer than ever befor...

Drug repurposing has lately received increasing interest in several diseases especially cancers, due to its advantages facilitating the development of new therapeutic strategies, by adopting a cost-friendly approach and avoiding strict Food Administration (FDA) regulations. Acriflavine (ACF) is an FDA approved molecule that been extensively studied since 1912 with antiseptic, trypanocidal, anti...

Adenylyl transferase (ATase) is the bifunctional effector enzyme in the nitrogen assimilation cascade that controls the activity of glutamine synthetase (GS) in Escherichia coli. This study addresses the question of whether the two antagonistic activities of ATase (adenylylation and deadenylylation) occur at the same or at different active sites. The 945 amino acid residue ATase has been trunca...

The genetic distance of 11 cotton genotypes varying in heat tolerance was studied using RAPD markers. Fifty-three random decamer primers were used for the estimation of genetic distance. Among the 53 RAPD primers, which were custom synthesized by GeneLink Inc., UK, 32 were polymorphic and 21 were monomorphic. The 32 polymorphic primers produced 273 fragments, with a mean of 8.3 fragments per pr...

1 Evidence of functional cross-talk between the Notch and NF-κB pathways in non-neoplastic 1 hyperproliferating colonic epithelium 2 3 4 Ishfaq Ahmed, Badal Roy, Parthasarathy Chandrakesan, Anand Venugopal, Lijun 5 Xia, Roy Jensen, Shrikant Anant, Shahid Umar 6 7 8 From Departments of Molecular and Integrative Physiology and Pathology and Laboratory 9 Medicine, University of Kansas Medical Cent...

Lab Chip This journal is © The Royal Society of Chemistry 2014 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. E-mail: [email protected]; Fax: +1 (913) 945 6373; Tel: +1 (913) 945 6327 Department of Chemistry, Ralph N Adams Institute for Bioanalytical Chemistry, and Bioengineering Graduate Program, University of Kansas, Lawrence, ...