Background. Radiosynovectomy (radiosynoviorthesis) is an important instrument for the effective local treatment of chronic inflammatory joint disease, and provides an alternative to surgical synovectomy. Radiosynovectomy leads to the restoration of synovium in the treated joint, with improved joint function due to reduction of pain, swelling and stiffness. The radiopharmaceutical agent used in ...

Interstitial irradiation using yttrium-90 (90Y) rods implanted by needle into the pituitary gland was used as primary treatment in 16 patients with pituitary dependent Cushing's disease. Clinical and biochemical remission was observed within three or six months in 13 and in the remaining three after a supplementary implant. There was no perioperative morbidity. Follow-up from the time of defini...

We have shown previously significant antitumor effects using 90Y-MN-14 anti-CEA monoclonal antibody (MAb) for radioimmunotherapy (RAIT) of human medullary thyroid cancer (MTC) xenografts using the TT cell line. The purpose of this investigation was to determine the effect of combining chemotherapy and RAIT with 90Y-MN-14 in MTC. In particular, the toxicity and efficacy of various dose schedules...

Background: Transarterial radioembolization (TARE) relies on directly injected 90Y- or 166Ho-loaded microspheres in the hepatic arteries. The activity to be is generally based pre-TARE 99mTc-macro-aggregated-albumin (MAA) imaging, while actual dose distribution post-treatment images. volume of interest (VOIs) propagation methods (i.e., rigid and deformable) from pre- post-TARE imaging might aff...

Introduction: Treatment efficacy of radiation therapy using Yttrium-90 radionuclide is evaluated by the bremsstrahlung SPECT imaging following radiation therapy. The radioisotopic images have the ability to provide reliable activity map of 90Y distribution. But these images have a low quantitative accuracy in the 90Y bremsstrahlung SPECT imaging, therefore the optimization of...

PURPOSE The use of 90Y-microspheres to treat unresectable liver metastases originating from a variety of neuroendocrine tumors was reviewed. MATERIALS AND METHODS This is a retrospective review from 10 institutions of patients given 90Y-microsphere therapy for neuroendocrine hepatic metastases. Physical, radiographic, biochemical, and clinical factors associated with treatment and response we...

A Phase II study of yttrium-90-tetra-azacyclododecanetetra-acetic acid-biotin (90Y-DOTA-biotin) pretargeted by NR-LU-10 antibody/streptavidin (SA) was performed. The primary objectives of the study were to evaluate the efficacy and safety of this therapy in patients with metastatic colon cancer. Twenty-five patients were treated with a single dose of 110 mCi/m2 (mean administered dose, 106.5 +/...

Image-guided interstitial brachytherapy is used for the treatment of primary and secondary liver tumors. Millions of nonbiodegradable yttrium-90 (90Y)-imprinted microspheres with a diameter of 29– 35 μmare selectively infused by a catheter into the branch of the hepatic artery supplying the tumor. Thereby, a radiation dose of 30–60Gy can be applied to the tumor tissue. 90Y is a beta-emitter wit...