نتایج جستجو برای: 886
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The effect of 3-[1-(p-chlorobenzyl)-5-(isopropyl)-3-tert-butylthioindol-2-yl]-2, 2-dimethylpropanoic acid (MK-886), a leukotriene biosynthesis inhibitor, on Ca mobilization in MadinDarby canine kidney cells has been examined by fluorimetry using fura-2 as a Ca indicator. MK-886 at 0.5 to 25 mM concentration dependently increased [Ca]i. The [Ca ]i increase comprised an immediate initial rise and...
Previous studies involving transfection of cDNAs for 5-lipoxygenase-activating protein (FLAP) and 5-lipoxygenase into osteosarcoma cells have shown that both these proteins are essential for leukotriene synthesis (Dixon, R. A. F., Diehl, R. E., Opas, E., Rands, E., Vickers, P. J., Evans, J. F., Gillard, J. W., and Miller, D. K. (1990) Nature 343, 282-284). In the present study we show that FLAP...
The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed to the Ca(2+) ionophore A23187, reaching maximal stimulation at 5.0 muM. This r...
s 886 (2013). 31 Urban D, Lewin J, Collins IM, Mooi J, Jefford M.Rechallenge with imatinib in GIST: is more alwaysRIGHT? Lancet Oncol. 15(1), e2–e3 (2013).
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