tricuspid isthmus mapping to assess bidirectional block during common atrial flutter radiofrequency ablation. Circulation 1999;100:2507–13. 11. Sacher F, Derval N, Jadidi A, Scherr D, Hocini M, Haissaguerre M et al. Comparison of ventricular radiofrequency lesions in sheep using standard irrigated tip catheter versus catheter ablation enabling direct visualization. J Cardiovasc Electrophysiol 2...

adequate National Tuberculosis Control Programme implementation. Int J Tuberc Lung Dis 2008; 12: 869–877. 7 World Health Organization. Public-Private Mix for TB Care and Control A toolkit. Geneva, WHO, 2010. WHO/HTM/TB/2010.12; available from www.who.int/tb/careproviders/ppm/PPMToolkit. pdf Date last updated: 2012; Date last accessed: February 8, 2012. 8 Malmborg R, Mann G, Squire SB. A systema...

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Epstein-Barr virus (EBV) is a tumorigenic herpes virus that infects and persists in B lymphocytes in the majority of humans, generally without causing disease. However, in a few individuals the virus is associated with significant pathology, particularly benign and malignant lymphoproliferations. Recently acquired knowledge on the mechanisms of EBV persistence, immune control of primary and per...

The German software industry is vital to the German economy's success. However, it has missed some current trends where software companies lack broader international activity. Existing models that take domestic market size into account can only partially explain the different degrees of internationalized companies between different countries. In addition, they are unable to explain individual c...

Linifanib (A 741439; A-741439; A741439; ABT-869; ABT869; RG3635) is an orally active multi-targeted receptor tyrosine kinase inhibitor for the treatment of various cancers. It was being developed by Roche but development has now reverted to Abbott. The compound is designed to inhibit vascular endothelial growth factor and platelet-derived growth factor receptors. It is in phase III development ...

Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine...

With ultracold 87Srconfined in a magic wavelength optical lattice, we present the most precise study (2.8 Hz statistical uncertainty) to date of the 1S0-3P0 optical clock transition with a detailed analysis of systematic shifts (19 Hz uncertainty) in the absolute frequency measurement of 429 228 004 229 869 Hz. The high resolution permits an investigation of the optical lattice motional sideban...

directed against Kv1.5 mRNA specifically inhibit ultrarapid delayed rectifier Kþ current in cultured adult human atrial myocytes. Circ Res 1997;80:572–579. 64. Nattel S, Yue L, Wang Z. Cardiac ultrarapid delayed rectifiers: a novel potassium current family of functional similarity and molecular diversity. Cell Physiol Biochem 1999;9:217–226. 65. McClellan KJ, Goa KL. Candesartan cilexetil. A re...

Alternative substrates for influenza vaccine production are needed to ensure adequate supplies. We evaluated the relative safety and immunogenicity of recombinant hemagglutinin (rHA) or trivalent inactivated vaccine (TIV) among 869 > or =65-year-old subjects in a randomized clinical trial. Virologic surveillance for influenza-like illness (ILI) was conducted during the 2006-2007 epidemic. Vacci...