there are wide individual differences in pharmacokinetic parameters of mycophenolate mofetil (mmf) among transplanted patients. some studies have shown that single nucleotide polymorphisms (snps) of the uridine diphosphate glucuronosyl transferase1a9 (ugt1a9) are responsible for these differences in early days after transplantation. therefore it was decided to evaluate the influence of ugt poly...

Ribavirin and mycophenolic acid (MPA) are known inhibitors of the IMPDH enzyme (E.C. 1.1.1.205). This enzyme catalyzes the conversion of inosine monophosphate to xanthine monophosphate, leading eventually to a decrease in the intracellular level of GTP and dGTP. The antiviral effect against bovine viral diarrhoea virus (BVDV) of 15 analogues related to MPA was determined. MDBK cells were infect...

the effects of desiccation and nacl and polyethylen glycol (peg) induced water potentials on rhizome bud sprouting of the perennial weed, glycyrrhiza glabra were investigated in separate laboratory experiments laid out in completely randomized designs. each treatment was replicated four times. the water potentials of nacl and peg used were 0, -0.4, -0.8, -1.2 and -1.6 mpa. desiccation experimen...

The article is devoted to the issues of obtaining pressed building materials based on dihydrate phosphogypsum. Dihydrate phosphogypsum after mechanical activation in a ball mill acquires ability harden specimens. After and its pressing at pressure 30 MPa, strength specimens increases by 6...8 times compared non-activated reaches 25...30 MPa. There found influence various chemical admixtures bin...

The aim of the current study was to determine for adult squaretail coralgrouper (Plectropomus areolatus) spatial requirements for effective and biologically meaningful marine protected area (MPA) design, based on reproductive and non-reproductive habitat use. To determine movement relative to spawning sites and identify non-reproductive home range areas, P. areolatus were re-located or tracked ...

Objective: To investigate the effects of different surface conditioning methods on shear bond strength (SBS) of metal brackets bonded to porcelain surfaces and the influence of silane coupling agent in altering the bond strength. Materials and methods: A total of 80 feldspathic porcelain specimens were used. They were divided into eight different groups based on different surface conditioning m...

recently, self-etching fissure sealants have been introduced to reduce technical sensitivity; however, their efficacy should be assessed. the aim of this study was to assess of the microshear bond strength of self-etching and conventional fissure sealants.thirty non-carious third molars were randomly divided into three groups (n=10). microcylinders of concise fissure sealant were bonded to prep...