Known 1,6-di(thiophen-2-yl)hexane-1,6-dione (2) and novel 1,7-di(thiophen-2-yl)heptane-1,7-dione (4) were obtained from the reactions of thiophene with corresponding diacyl chlorides. Furthermore, compounds furan pyrrole units in place compound 2 same way. Bromination 4 gave bromides regioselectively. The reaction each HOAc medium yielded cyclocondensation products. In total, four known eleven ...

To continue our systematic SAR studies a series of N-phenylamino derivatives of 2-azaspiro[4.4]nonane-, 2-azaspiro[4.5]decane-, 6-methyl-2-azaspiro[4.5]decane-1,3-dione and 3-cyclohexylpyrrolidine-2,5-dione were synthesized and tested for their anticonvulsant activity in the maximum electroshock seizure (MES) and subcutaneous metrazole seizure threshold (sc. Met) tests. Among those molecules th...

U rsel S tuh lem m er, W ern er H aussm ann , F ran k M ilek , W olfgang K reis, and E rn s t R e in h a rd Pharmazeutisches Institut, Eberhard-Karls-Universität, A uf der Morgenstelle 8 D-72076 Tübingen, Bundesrepublik Deutschland Z. Naturforsch. 48 c, 713-721 (1993); received July 23,1993 Digitalis lanata, Biotransformation, Cardenolide Biosynthesis, Cell-Free System, 3 a-Hydroxysteroid-5 ß-o...

A rapid and high yield microwave assisted synthesis of a series novel 7,9-bis-(arylidene)-4-methyl-2,6,10-triphenyl-2,3-diazaspiro[4,5]dec-3- -ene-1,8-dione has been explored. The spiro diarylidene derivatives having nitrogen atom ?,?-unsaturated ketone moiety were synthesized by aldol condensation between 4-methyl-2,6,10-triphenyl-2,3-diazaspiro[4,5]dec-3-ene-1,8- -dione corresponding aryl ald...

We have studied the developmental changes of glutamate-induced calcium (Ca²⁺) response in primary cultured hippocampal neurons at three different stages of cultures, 3, 7-8, and 14-16 days in vitro (DIV), using fura-2 single-cell digital micro-fluorimetry. We found that glutamate-induced Ca²⁺ signaling was altered during development, and that two different ionotropic glutamate receptors, α-amin...