Christia vespertilionis (L.f.) Bakh. f. is an ornamental plant with unique butterfly-shaped leaves, hence its vernacular name “butterfly wing” or “rerama” in Malay. In Malaysia, the green-leafed variety of this has gained popularity recent years due to testimonial reports by local consumers medicinal uses, which include treatment for cancer. Despite these popular there very limited information ...

The potential use of polyphenols in the prevention and treatment of chronic inflammatory diseases has been extensively investigated although the mechanisms involved in cellular signaling need to be further elucidated. Cyanidin-3-glucoside is a typical anthocyanin of many pigmented fruits and vegetables widespread in the human diet. In the present study, the protection afforded by cyanidin-3-glu...

D. Montanari,1,* S. Leoni,1,2,† L. Corradi,3 G. Pollarolo,4 G. Benzoni,2 N. Blasi,2 S. Bottoni,1 A. Bracco,1,2 F. Camera,1,2 A. Corsi,1,2 F. C. L. Crespi,1,2 B. Million,2 R. Nicolini,1,2 O. Wieland,2 G. de Angelis,3 F. Della Vedova,3 E. Fioretto,3 A. Gadea,5 B. Guiot,3 D. Mengoni,3,6 D. R. Napoli,3 R. Orlandi,3,‡ F. Recchia,7 A. M. Stefanini,3 R. P. Singh,3 J. J. Valiente-Dobon,3 D. Bazzacco,8 ...

The crystal structures of three isomeric compounds of formula C14H13Cl2NO2S, namely 3,5-di-chloro-N-(2,3-di-methyl-phen-yl)-benzene-sulfonamide (I), 3,5-di-chloro-N-(2,6-di-methyl-phen-yl)benzene-sulfonamide (II) and 3,5-di-chloro-N-(3,5-di-methyl-phen-yl)benzene-sulfonamide (III) are described. The mol-ecules of all the three compounds are U-shaped with the two aromatic rings inclined at 41.3 ...

J.-C. Walter, 2 M. Baiesi, 4 G. T. Barkema, 1 and E. Carlon Instituut-Lorentz, Universiteit Leiden, P.O. Box 9506, 2300 RA Leiden, The Netherlands Institute for Theoretical Physics, KULeuven, Celestijnenlaan 200D, Leuven, Belgium Dipartimento di Fisica e Astronomia, Università di Padova, Via Marzolo 8, Padova, Italy INFN, Sezione di Padova, Via Marzolo 8, Padova, Italy Institute for Theoretical...

In order to investigate SAR regarding proximal phenyl ring in novel C-aryl glucoside SGLT2 inhibitors containing a thiazole motif, a series of chemical modifications on proximal phenyl ring was conducted. During a series of lead optimization efforts, ortho-allyloxyphenyl 10p or ortho-hydroxyphenyl 11a showed subnanomolar inhibitory activity against hSGLT2.

Dipartimento di Chimica and Centro di E Studi di Milano, UdR dell'INSTM, via G [email protected]; elena.cariat Istituto di Scienze e Tecnologie Molecolar dell'INSTM, via Golgi 19, 20133 Milano, Ita Istituto per lo Studio delle Macromolecole Milano, Italy Dipartimento di Scienza dei Materiali, Uni Cozzi 53, I-20125 Milano, Italy Dipartimento di Fisica e Astronomia “Gali Padova, via Mar...

As part of our continuing efforts in the search for potential biologically active compounds from medicinal plants, we have isolated 18 compounds including two novel nitrogen containing diterpenes from extracts of the fruits of Vitex agnus-castus. These isolates, along with our previously obtained novel compound vitexlactam A (1), were evaluated for potential biological effects, including cancer...

The Fusarium mycotoxin zearalenone (ZEN) can be conjugated with polar molecules, like sugars or sulfates, by plants and fungi. To date, the fate of these modified forms of ZEN has not yet been elucidated in animals. In order to investigate whether ZEN conjugates contribute to the total ZEN exposure of an individual, ZEN (10 µg/kg b.w.) and equimolar amounts of two of its plant metabolites (ZEN-...