A combination of hyperthermia with radiotherapy and chemotherapy for various solid tumors has been practiced clinically. However, hyperthermic therapy has side effects, such as thrombocytopenia. Up to now, the pathogenesis of hyperthermia-induced thrombocytopenia remains unclear. Previous studies have shown that hyperthermia induces platelet apoptosis. However, the signaling pathways and molecu...

BACKGROUND AND PURPOSE Experimental studies have shown that hyperthermia is a determinant of poor outcome after ischemic stroke. Clinical studies evaluating the effect of temperature on poststroke outcome have, however, been limited by small sample sizes. We sought to evaluate the effect of temperature and timing of hyperthermia on outcome after ischemic stroke. METHODS Data of 5305 patients ...

Introduction: Febrile seizures are the most common seizure disorder in childhood and its prevalence is estimated to be 2 to 5 percent. There is a relationship between the use of corticosteroids and seizures. This study investigated the effects of dexamethasone pretreatment on convulsive behavior caused by hyperthermia. Methods: In this study, 24 rats aged 19-20 days were divided into 3 groups (...

BACKGROUND In the care of patients with traumatic injuries, focus is placed on hypothermia secondary to its deleterious impact on the coagulation cascade. However, there is scant information on the mortality effect of hyperthermia. STUDY OBJECTIVES We hypothesized that both hypothermia and hyperthermia are associated with decreased survival in patients with traumatic injuries. Furthermore, we...

People who become hyperthermic during exercise display large increases in heart rate (HR) and reductions in stroke volume (SV). It is not clear if the reduction in SV is due primarily to hyperthermia or if it is a secondary effect of an elevation in HR reducing ventricular filling. In the present study, the upward drift of HR during prolonged exercise was prevented by a very small dose of the β...

Hyperthermia is a promising anticancer treatment modality. Heat stress stimulates proteolytic machineries to regulate cellular homeostasis. Calpain, an intracellular calcium (Ca 2+ )-dependent cysteine protease, modulator that governs various functions. induces increase in cytosolic Ca levels and triggers calpain activation. Contrastingly, pre-exposure of cells mild hyperthermia thermotolerance...

This study describes the sensitization mechanism to thermal stress by histone deacetylase inhibitors (HDACIs) in lung cancer cells and shows that Ku70, based on its acetylation status, mediates the protection of lung cancer from hyperthermia (42.5°C, 1-6 hrs). Ku70 regulates apoptosis by sequestering pro-apoptotic Bax. However, its role in thermal stress is not fully understood. The findings sh...

Multifunctional nanoprobes have great potential as effective radiosensitizers and drug carriers. RGD-modified gold nanorods could increase the uptake of nanoparticles via receptor-mediated endocytosis in integrin alphaV beta3-overexpressing breast cancer cells, which could enhance the effects of radiation on tumor cells, leading to further radiosensitization. The purpose of our study was to dem...

More than 20 years ago, it was hypothesized that intracellular hyperthermia is superior to extracellular hyperthermia. It was further hypothesized that even a single biological cell containing magnetic nanoparticles can be treated for hyperthermia by an AC magnetic field, independent of its surrounding cells. Since experimental investigation of the thermal effects of intracellular hyperthermia ...

Hyperthermia, not uncommon in severe brainstem stroke, is frequently difficult to control and associated with a poor prognosis and high mortality. Successful treatment of central hyperthermia in patients with brainstem infarction by baclofen has not been described. Following basilar artery occlusion, a 68-year-old female developed prolonged hyperthermia. Her hyperthermia did not respond to any ...