Standardisation of Ayurvedic medicines has become necessary to keep up their therapeutic efficacy. This paper deals with the standardization of Thaleesapatradi Choornam, a compound preparation of six drugs along with sugar. Chromatographic technique was used for the detection of the ingredients. Different solvent systems were developed for each ingredient, and spots obtained were visualized in ...

Objective We have recently discovered new gastric lesions with black spots. There have been no reports about black spots and their clinicopathological features. We therefore report the clinicopathological features of black spots and assess their causes and mechanisms. Methods Sixty-four patients with black spots among 26,620 Japanese patients that underwent endoscopy between May 2012 and Octobe...

BACKGROUND Keratins 8/18 (K8/K18) are established hepatoprotective proteins and K8/K18 variants predispose to development and adverse outcome of multiple liver disorders. The importance of K8/K18 in alcoholic liver disease as well as in established cirrhosis remains unknown. METHODS We analyzed the K8 mutational hot-spots in 261 prospectively followed-up patients with alcoholic cirrhosis (mea...

Meiotic recombination, crucial for proper chromosome segregation and genome evolution, is initiated by programmed DNA double-strand breaks (DSBs) in yeasts and likely all sexually reproducing species. In fission yeast, DSBs occur up to hundreds of times more frequently at special sites, called hot spots, than in other regions of the genome. What distinguishes hot spots from cold regions is an u...

Pancreatic cancer (PC) is one of the most lethal malignant tumors because of late diagnosis and the lack of response to various therapies. To identify potential biomarkers in cancerous serum from early stage PC patients, we carried out two-dimensional gel electrophoresis (2-DE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to compare the serum proteomic profiles from 45 patients...

We assayed more than 5000 blood spots dried on filter paper and approximately 1000 serum samples for immunoreactive trypsin, with commercial reagents (Behring and Sorin). The assay procedures were modified so that newborn screening is technically feasible. Both kits are satisfactory for serum assay, but the Sorin materials are better adapted for blood spot analysis. Immunoreactive trypsin in bl...

In a mill spinning coarse cotton the prevalence of byssinosis and other respiratory symptoms, and the F.E.V.1.0, were measured in a group of 29 men and I117 women employed in the winding room. All the men and 95% of the women at risk were included. Dust concentrations, measured with a modified Hexhlet at various work points in the winding room, ranged from i-65 to 6 o5 mg. Jm.3 total dust. Thes...