Bariatric surgery is the most effective long term weight-loss therapy for severe and morbidly obese patients. Melanocortin-4 Receptor (MC4R) mutations, the most frequent known cause of monogenic obesity, affect the regulation of energy homeostasis. The impact of such mutations on weight loss after bariatric surgery is still debated.The objective is to determine the impact of MC4R status on weig...

Rectal methohexital has been used for nearly 30 yr in pediatric anesthesia. Despite this long and increasingly varied use, no large prospective series has been published detailing safety and efficacy. This study prospectively evaluated the efficacy, safety, and side effects of this medication in a series of 648 cases. On 553 of 648 occasions (85%), the child fell asleep after a single 30-mg/kg ...

OBJECTIVES We aimed to evaluate the incidence and clinical features of vascular stump thrombus after oncologic lung surgery. METHODS A retrospective analysis of records from our institutional database dated between 2009 and 2016 was performed. Data regarding demographics, clinical presentation, medication use, operative findings, pathology, and radiologic findings were retrieved. RESULTS Th...

ALCOHOLISM AND THE ALCOHOL USE DISORDERS 620 HISTORICAL INTRODUCTION AND ISSUES FOR THE FIELD 621 EPIDEMIOLOGY 623 A MULTILEVEL NET FOR DEVELOPMENTAL VARIATION 625 VARIATIONS IN RISK AND COURSE OF THE DISORDER 628 Differences in Alcohol Nonspecific-Risk Structure for Later Disorder Are Present in Early Childhood 629 Heterogeneity in the Course of Risk and Heterogeneity of Nonspecific Risk 632 H...

Reactive oxygen species (ROS) and IRF1 stimulate IFNα production by 1 proximal tubules during ischemic AKI. 2 Pamela D. Winterberg, Yanxia Wang, Keng-Mean Lin, John R. Hartono, Glenn T. Nagami, Xin J. Zhou, 3 John M. Shelton, James A. Richardson, and Christopher Y. Lu . 4 5 Author Contributions: PDW and YW contributed equally to the majority of experimental data presented; PDW 6 participated in...

FGF23 Decreases Renal NaPi-2a and NaPi-2c Expression and Induces 1 Hypophosphatemia In Vivo Predominantly Via FGF Receptor 1 2 3 Jyothsna Gattineni, Carlton Bates, Katherine Twombley, Vangipuram 4 Dwarakanath, Michael L. Robinson, Regina Goetz, Moosa Mohammadi 5 and Michel Baum 2 6 7 8 Department of Pediatrics and Internal Medicine 9 10 University of Texas Southwestern Medical Center at Dallas ...

Introduction: Rotavirus is the leading cause of severe diarrhea in infants and young children. Rotavirus immunization has been effective in developed countries, where the genotype G1P[8] is the predominant Rotavirus strain. Objective: The present study was therefore undertaken to assess the Rotavirus prevalence, genotypes and to know the circulating strains in a population. Materials and Method...

We discuss three aspects of post-AGB (PAGB) stars in old populations. (1) HST photometry of the nucleus of the planetary nebula (PN) K 648 in the globular cluster (GC) M15 implies a mass of 0.60 M , in contrast to the mean masses of white dwarfs in GCs of ∼0.5M . This suggests that K 648 is descended from a merged binary, and we infer that single Pop II stars do not produce visible PNe. (2) Yel...

Evidence suggests that education protects from dementia by enhancing cognitive reserve. However, this may be influenced by several socio-demographic factors. Rising numbers of dementia in India, high levels of illiteracy and heterogeneity in socio-demographic factors provide an opportunity to explore this relationship. Objective To study the association between education and age at dementia o...

Background Alzheimer’s disease (AD) not only effects the cognitive level, but also leads to significant decline in motor skill. Manual dexterity emerges with interaction of and processes is seen as an important predictor functional independence. The aim this study was compare manual people AD healthy older adults investigate effect level on dexterity. Method Nine Hole Peg Test (NHPT) used for a...