5′-Methylthioadenosine (MTA) is a natural substrate of MTA phosphorylase (MTAP) and converted to adenine via salvage pathway for AMP production in normal healthy cells. The lack MTAP expression many solid tumors hematologic malignancies compared cells has been explored potential therapeutic strategy selectively target tumor using antimetabolites such as 5-fluorouracil (5-FU) 6-thioguanine (6-TG...

BACKGROUND Patients with severe psoriasis may be unresponsive to or unable to tolerate the adverse effects of traditional therapy. Thioguanine has been used to treat psoriasis, but experience is limited. Most previous studies have used daily therapy and have demonstrated significant hematologic abnormalities. OBJECTIVE To reduce the adverse effects of traditional thioguanine therapy, our stud...

Objective: In this prospective study, we examined the association between azathioprine dose, levels of its phosphoribosylated metabolites, and the activity of thiopurine methyltransferase in patients with multiple sclerosis (MS). Materials/Methods: Clinical data and blood samples were collected from 27 MS patients who were undergoing azathioprine treatment. In red blood cells, thiopurine methyl...

of MMPR forms rapidly to levels of 1 to 2 mM in the tumor cells, and the steady-state levels of 5-phosphoribosyl 1-pyrophosphate increase 4to 5-fold in 6 to 12 hr. This permits a significantly greater synthesis of 6-thioguanosine monophosphate (6-thioGMP) after injection of 6-thioguanine. These findings are similar to those in previous reports concerning the synergism between 6-mercaptopurine a...

Aim: To determine the concentration of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP), interpatient variability, relationship with disease activity in patients Chron’s on long-term stable doses azathioprine (AZA). Methods: This is a prospective, tertiary care single-center hospital study adult treated AZA. The quantification phenotypic thiopurine methyltransferase enzyme re...

Granulocytic sarcoma is an unusual variant of myeloid malignancy most commonly encountered in the course of chronic or acute myeloid leukaemia. Of 60 patients of chronic myeloid leukaemia studied over 21 months, we encountered 6 (10%) cases of granulocytic sarcoma. Four of these had granulocytic sarcoma on their first presentation. All those who were receiving hydroxyurea did not fare well but ...

The [Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph(3)PAu(6-MP)] and [Ph(3)PAu(6-TG)], where 6-TGH is 6...