A well-established finding in research on concepts and categories is that some members are rated as better or more typical examples than others. It is generally thought that typicality reflects centrality, that is, that typical examples are those that are similar to many other members of the category. This interpretation of typicality is based on studies in which participants had little knowled...

The Resolution of Public Health Committee Polish Academy Science on Vaccination against COVID-19 health community worldwide encouraged by successes former campaigns have always accepted vaccination as the most effective way to handle infectious diseases pandemics. Even before outburst SARS-CoV-2 pandemic in many countries mandatory diseases, especially child related had been implemented. From a...

Many decisions can be affected by certain types of interaction effects among and between some criteria of a coherent family of criteria, as for example, those resulting from a synergy or a redundancy phenomenon. However, in real-world decision aiding situations the relevant interactions (which should be modeled) are those that generally occur only between a small number of criteria pairs. Prese...

Amniotic band sequence (ABS) is the term applied to a wide range of congenital anomalies, most typically limb and digital amputations and constriction rings, that occur in association with fibrous bands (1). These alterations may be associated or not with cutaneous and visceral abnormalities. This work, which is a literature review, examines several studies that relate to cases of amniotic band...

Recent data suggest that the role of CYP3A4 in imatinib metabolism is smaller than presumed. This study aimed to evaluate the quantitative importance of different cytochrome P450 (P450) enzymes in imatinib pharmacokinetics. First, the metabolism of imatinib was investigated using recombinant P450 enzymes and human liver microsomes with P450 isoform-selective inhibitors. Thereafter, an in silico...

Square-wave cathodic adsorptive stripping voltammetry based on adsorptive accumulation is a very sensitive technique for the trace determination of xanthosine 50-monophosphate (50-XMP) and xanthosine 50-diphosphate (50-XDP). The determination is based on the strong interaction of the adsorption of xanthosine phosphate compounds on a mercury electrode surface, forming Hg(II)-xanthate. The cathod...

We analyzed RXTE data of GRS 1915+105 of X-ray low states between 1996 and 1998. The X-ray spectrum is dominated by the power law component. We found (i) that the power law is pivoting at 10-30 keV, (ii) that the power law slope correlates with radio flux, (iii) three different groups of 3-10 keV residuals, (iv) that one of these residual groups correlates with the power law slope. The prototyp...

Selpercatinib (LOXO-292) is a highly selective and potent inhibitor of RET signaling. In the LIBRETTO-001 Phase I/II trial, selpercatinib treatment resulted in 64% objective response rate (ORR) (95% confidence interval [CI]: 54-73%) registration dataset (n=105) patients with RET+ NSCLC who previously received platinum-based chemotherapy an 85% ORR CI: 70-94%) treatment-naïve (n=39). Although du...

Advective accretion disks and winds are the most self-consistent solutions today. We describe this paradigm briefly and show how it attempts to explain some of the interesting observations of the galactic microquasar GRS1915+105.