Abstract BACKGROUND Diffuse midline gliomas (DMGs) are a universally fatal brain tumor of childhood. While histone mutations critical initiating event, they insufficient to drive gliomagenesis. Histone co-occur with somatic alterations in other pathways including TP53, MAPK, and MYC signaling. However, the mechanisms through which these activated have not been fully elucidated. METHODS We appli...

Abstract Immortality is a fundamental hallmark of human cancer cells and therapeutic reversal great interest. Telomerase Reverse Transcriptase promoter (TERTp) mutations reactivate TERT expression, the rate limiting step in telomerase activity cellular immortality. TERTp are most common non-coding mutation across all types, including glioblastoma (GBM), oligodendroglioma, medulloblastoma, high-...

You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Urethral Reconstruction (including Stricture, Diverticulum) I (MP03)1 Sep 2021MP03-14 DURABLE TREATMENT OF REFRACTORY VESICOURETHRAL ANASTOMOTIC STENOSIS VIA ROBOTIC-ASSISTED RECONSTRUCTION: A TRAUMA AND UROLOGIC RECONSTRUCTIVE NETWORK SURGEONS STUDY Nabeel Shakir, Nejd Alsikafi, Julia Buesser, Gregory Amend, Benjamin Breyer, Jil...

Abstract Adoptive regulatory T-cell (Treg) therapy is an emerging therapeutic paradigm for promoting immune tolerance in transplant and autoimmune disease settings. Prior investigations demonstrate that murine Tregs can undergo epigenetic reprogramming within chronically inflamed tissue environments, resulting acquisition of proinflammatory functions the capacity to exacerbate damage. Despite r...