Genotypic analysis of 103 multidrug-resistant Mycobacterium tuberculosis strains isolated in Germany in 2001 revealed that mutations in codon 531 (75.7%) of the rpoB gene and codon 315 (88.4%) of the katG gene are most frequent. Beijing genotype strains (60.2% of all isolates) displayed a different distribution of resistance mutations than non-Beijing strains.

From August 1982 through March 1988, 531 patients have undergone continent urinary diversion using an ileal reservoir constructed according to the method of Kock. For the last 18 months we have used the principle of Kock reservoir construction for primary lower urinary tract reconstruction after cystectomy in 39 highly selected male patients by means of a ureteroileal urethrostomy. Early compli...

“Fachbereich fir Bauingenieurwesen, Labor fir Abfallwirtschaft, Siedlungswasserwirtschaft, Umweltchemie (LASU) , Fachhochschule Mtinster, D-48149 Mtinster, Germany ‘Pharmazeutisches lnstitut Poppelsdorf, Rheinische FriedrichWilhelmsUniversittit Bonn, Kreuzbergweg 26, D-531 15 Bonn, Germany ‘Departamento de Microbiologia, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain dDepart...

The cyclooxygenases (COX-1 and COX-2) oxygenate arachidonic acid (AA) in the committed step of prostaglandin biogenesis. Substitutions of I434V, H513R, and I523V constitute the only differences in residues lining the cyclooxygenase channel between COX-1 and COX-2. These changes create a hydrophobic pocket in COX-2, with Arg-513 located at the base of the pocket, which has been exploited in the ...

PURPOSE To investigate the cellular expression of cis-acting splicing mutations in the rhodopsin gene (RHO) that lead to autosomal dominant or recessive retinitis pigmentosa (adRP/arRP) and the role of nonsense-mediated mRNA decay (NMD) in its pathogenic mechanism. To design a potential therapeutic RNAi-based suppression strategy for cis-acting adRP splicing mutants. METHODS Cells were transf...

Complex I has reactive thiols on its surface that interact with the mitochondrial glutathione pool and are implicated in oxidative damage in many pathologies. However, the Cys residues and the thiol modifications involved are not known. Here we investigate complex I thiol modification within oxidatively stressed mammalian mitochondria, containing physiological levels of glutathione and glutared...

Vol. 7, No. 3 Supplement, June 2001 Emerging Infectious Diseases 531 Currently, there is no cohesive national system of laboratories to support community health activities. One vision for such a system would be a cooperative arrangement of public health, hospital and independent laboratories that address community needs (R.A. Martin, pers. comm., 2000; 13). The rationale for this system include...

Sebastián Bellú y Marcela Rizzotto* Area Inorgánica, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina Nora Okulik Facultad de Agroindustrias, Universidad Nacional del Nordeste, Cte. Fernández 755 (3700) Presidencia Roque Sáenz Peña, Chaco, Argentina Alicia Jubert Departamento de Química, Facultad de Ciencias Exactas 47 y 115 y Facultad de Ingeniería 1 y 47, Universidad Nac...

Department of Chemistry, Beijing Normal U [email protected]; [email protected]; Fax: Institut für Anorganische und Analyti Braunschweig, Hagenring 30, 38106 Brau tu-bs.de; Fax: +49-531-3915387; Tel: +49-53 † Electronic supplementary information ( all stationary points optimized at B3PW9 For ESI and crystallographic data in CI 10.1039/c5sc01684c ‡ These authors contributed equally to th Cite this: ...