نتایج جستجو برای: 527
تعداد نتایج: 2455 فیلتر نتایج به سال:
Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 380 6.7 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337 5.9 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 324 5.7 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 682 12.0 20 to 24 years . . . . . . . . . . . . . . . . . . . . ...
SIRT6 is a protein deacetylase, involved in various intracellular processes including suppression of glycolysis and DNA repair. Aldose Reductase (AR), first enzyme of polyol pathway, was proposed to be indirectly associated to these SIRT6 linked processes. Despite these associations, presence of SIRT6 based regulation of AR still remains ambiguous. Thus, regulation of AR expression by SIRT6 was...
BACKGROUND Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UV...
We have previously confirmed, using a rat mesenteric arteriole thrombolysis model, that thrombin inhibition induces endogenous thrombolysis in vivo. In addition, we have shown that thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role in the down regulation of endogenous thrombolysis. However, the mechanism of endogenous thrombolysis or spontaneous plasmin generation in vivo remains u...
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