Five halogen substituted pyrazolates, 4-chloro-3,5-diisopropylpyrazole (4-Cl-3,5-iPr2pzH), 4-bromo-3,5-diisopropylpyrazole (4-Br-3,5-iPr2pzH), 4-iodo-3,5-diisopropylpyrazole (4-I-3,5-iPr2pzH), 4-chloro-3,5-diphenylpyrazole (4-Cl-3,5-Ph2pzH), and 4-bromo-3,5-diphenylpyrazole (4-Br-3,5-Ph2pzH), were conveniently prepared by halogenation of the appropriate pyrazoles with N-halosuccinimides (NXS) (...

A simple, efficient, and environmentally friendly protocol for the synthesis of 1,3,5-triarylpyrazole in [bimm][PF6] ionic liquid mediated by Cu(OTf)2 is described. The reaction protocol gave 1,3,5-triarylpyrazoles in good to high yields (71-82%) via a one-pot addition–cyclocondensation between hydrazines and chalcones, and oxidative aromatization without requirement for an additional oxidizing...

The Cover Feature shows light-driven hydrogen evolution mediated by cobalt(II) tripodal iminopyridine complexes, using tri(n-butyl)triazatriagulenium (TATA+) as the organic sensitizer and triethylamine (TEA) sacrificial donor in aqueous acetonitrile. activity of complexes depends highly on electronic properties substituents pyridine moieties. Under acidified conditions, for H2 production was en...

Selective synthesis of 4-(sulfonyl)-methyl-1H-pyrazoles and (E)-4,5-dihydro-1H-pyrazoles from N-allenic sulfonylhydrazones with sulfonyl group migrations has been developed. A key feature of these reactions is that the migrations of the sulfonyl groups to different positions can be controlled by changing the Lewis acids.

A convenient one-pot Mannich-type-cyclization-oxidation tandem process has been developed for the synthesis of 1,3,5-trisubstituted pyrazoles derivatives from aldehydes, hydrazines and alkynes using p-toluenesulfonic acid monohydrate (PTSA) as a multifunctional catalyst. This method provides a flexible and rapid route to 1,3,5-trisubstituted pyrazoles.

Ring a ding: The first catalytic enantioselective total synthesis of the meroterpenoid natural product (+)-liphagal is disclosed. The approach showcases a variety of technology including enantioselective enolate alkylation, a photochemical alkyne-alkene [2+2] reaction, microwaveassisted metal catalysis, and an intramolecular aryne capture cyclization reaction. Pivotal to the successful completi...

In recent years, zinc oxid nanotubes have attracted much attention. The direct use of , zinc oxidnanotubes modified by SiO2 as recoverable catalysts for organic reactions is very rare. The catalystswere characterized by XRD. The average particle size of ZnO catalysts is 57 nm and there are highdensitydefects on nanotubes surfaces . A simple and efficient method for the imidazol derivativessynth...