In view of potential biological activities of small molecule polyamides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamide (7a,b), and N-(2-(1-benzyl-2-(alkylthio) -1H-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamides (8a,b) as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at c...

2 Principles 4 2.1 Stochastic dynamics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.2 First law . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2.3 Entropy production . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.4 Jarzynski relation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.5 Optimal finite-t...

3′-methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic acid was synthesized using diverse conditions. The best reaction condition consisted of water as solvent under microwave irradiation, affording product in 76% yield.