The aim of the present study was to determine whether serum miR-499 may be used as a biomarker for early detection of non-small cell lung cancer (NSCLC). The present study was designed as an initial screening phase and a subsequent validation phase. In the screening phase, we analyzed serum levels of miR-499 in a subset of 40 patients with stage I (n=20) and stage IV (n=20) NSCLC. In the valida...

Background: Colorectal cancer is the fourth most common cancer, in terms of incidence throughout the world. There are some differences for risk factors involved in the incidence of tumor in different anatomical subsites of large bowel. However, most investigations have not studied the association between dietary factors and colorectal cancer subsites. Thus the current ecological study inves...

Background: Metastasis and recurrence of colorectal cancer after treatment is attributed to stem cells. The aim of this study was to determine the relationship between the expression of stem cell marker CD166 in colorectal cancer by immunohistochemistry and clinicopathologic parameters.Methods: From 2006 to 2012, 121 colectomy specimens of patients with colon cancer that were operated in Babol...

MicroRNAs (miRNAs) are small non-coding RNA molecules, which participate in diverse biological processes and may regulate tumor suppressor genes or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNA may contribute to diverse functional consequences, including cancer development, by altering miRNA expression. Numerous studies have shown the association between miRNA SNPs and cancer risk;...

aim : the aim of this study was to compare prognostic factors between colon and rectal cancers. background : prognosis of colorectal cancer (crc) may depend on the anatomical site. patients and methods : a total of 1219 patients with crc diagnosis according to the pathology report of rcgld cancer registry, from 1 january 2002 to 1 october 2007, were entered into the study. demographic and clini...

An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the association between the rs3746444 polymo...

objective(s):transforming growth factor-β(tgf-β) is involved in colorectal cancer (crc). the sd-208 acts as an anti-cancer agent in different malignancies via tgf-β signaling. this work aims to show the effect of manipulation of tgf-β signaling on some mirnas implicated in crc. materials and methods: we investigated the effects of sd-208 on sw-48, a colon adenocarcinoma cell line. the cell line...

Benign neoplasms of the colon, rectum, anus and anal canal are true neoplasia colon mucosa associated with a high risk colorectal cancer (CC). The literature review analyzes epidemiology, factors, modern methods diagnosis treatment, describes priority minimally invasive interventions for benign tumors.

Green synthesis of mPEG–PLGA and nanoformulation for delivery irinotecan to colon cancer.