We report the crystal structure of a binary complex of human peroxisomal carnitine acetyltransferase and the substrate l-carnitine, refined to a resolution of 1.8 Angstrom with an R(factor) value of 18.9% (R(free)=22.3%). L-carnitine binds to a preformed pocket in the active site tunnel of carnitine acetyltransferase aligned with His(322). The quaternary nitrogen of carnitine forms a pi-cation ...

The aim of this work was to study the central corneal thickness values and interobserver variability using a noncontact specular microscope. Methods: 62 eyes from 31 healthy subjects were studied with the Topcon SP-2000P noncontact specular microscope (Topcon Corp., Tokyo, Japan). 16 (51.61%) were females, and 15 (48.38%) were males. The mean age of the sample was 31.83±5.68 years. The mean of ...

OBJECTIVE The objective of the present study was to investigate the pain on injection of articaine with adrenaline, prilocaine with phenylpressin , and lidocaine with adrenaline. STUDY DESIGN The study sample was comprised of 497 consecutively seen patients received 497 maxillary buccal infiltration injections or inferior alveolar block injections of 4% articaine with 1:200.000 adrenaline, 3%...

TABLE OF CONTENTS INTRODUCTION ..................................................................................... 468 I. A BRIEF SUMMARY OF WAL-MART STORES, INC. V. DUKES .............. 471 II. STATISTICAL METHODOLOGY AND GROSS DISPARITIES OF DISCRIMINATION ........................................................................ 474 A. Commonality and Its Intricate Relationship with Sampling...

INTRODUCTION........................................................................................ 484 I. THE PUZZLES OF ENTRY............................................................. 488 A. The Assumption of Entrant Rationality: Empirical Findings vs. Economic Theory ............................................ 488 1. The First Puzzle: The Prevalence of Negative Net Present Value Entry ....

Abnormal expression of long non-coding RNA (lncRNAs) often contributes to unrestricted growth and invasion of cancer cells. LncRNA XIST expression is up-regulated in several cancers, however, its modulatory mechanism in gastric cancer (GC) has not been elucidated. In the present study, we found that XIST expression was significantly increased in GC tissues and cell lines. LncRNA XIST promoted c...

Epidemiology and Transmission 487 Staphylococcus aureus 487 Coagulase-Negative Staphylococci 488 Microbiology 489 Staphylococcus aureus 489 Coagulase-Negative Staphylococci 490 Pathogenesis of Disease 490 Virulence Factors of Staphylococcus aureus 490 Epithelial Attachment and Invasion 490 Innate Immune Resistance 491 Secreted Toxins 492 Quorum Sensing and Regulation of Virulence Factor Express...

In recent years, nuts have received special attention because of their potential role in preventing cardiovascular disease. Because nuts are very rich in total fat that can potentially be oxidized and their skins contain several antioxidants, studies have been conducted to evaluate the potential effect of nut consumption on oxidative stress. This review evaluates the in vitro and in vivo studie...