نتایج جستجو برای: 468

تعداد نتایج: 3255  

2017
Mansoor ALETAHA Behzad MANSOORI Ali MOHAMMADI Mehdi FAZELI Behzad BARADARAN

BACKGROUND Breast cancer is the most common diagnosed cancer among women in the world. Snail1 plays a role in the development of the invasive phenotypes of cancer, neural cell differentiation, cell division and apoptosis in tumor cells. Traces of snail1 in metastasis of breast cancer to bone are observed. The aim of this study was to investigate the effect of specific snail1 siRNAs on the proli...

2016
Lei Song Nadia Falzone Katherine A. Vallis

Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed a facile synthetic method of radiolabeling indium-111 (111In) to epidermal growth factor (EGF)-gold nanoparticles (111In-EGF-Au NP) with a high payloa...

Journal: :The Journal of pharmacology and experimental therapeutics 2012
Un-Ho Jin Syng-ook Lee Stephen Safe

Leflunomide, flutamide, nimodipine, mexiletine, sulindac, tranilast, 4-hydroxytamoxifen, and omeprazole are pharmaceuticals previously characterized as aryl hydrocarbon receptor (AHR) agonists in various cell lines and animal models. In this study, the eight AHR-active pharmaceuticals were investigated in highly aggressive aryl hydrocarbon (Ah)-responsive BT474 and MDA-MB-468 breast cancer cell...

Journal: :European review for medical and pharmacological sciences 2017
T-Y Tang X-X Zhou H Huang Q-D Huang

OBJECTIVE To explore the relationship between obstructive sleep apnea syndrome (OSAS) and polymorphism in the IL-1β gene. PATIENTS AND METHODS We recruited 164 OSAS patients to the observation group and 146 healthy people to the control group during the same period. Using RFLP (Restriction Fragment Length Polymorphism), we detected higher G/G and C/C rates on locus 154 of the IL-1β gene in th...

Journal: :Molecular cancer research : MCR 2006
Philipp Bastian Birte Posch Kerstin Lang Bernd Niggemann Kurt S Zaenker Hanns Hatt Frank Entschladen

The polarization of tumor cells and leukocytes into a front end and a rear end is a crucial prerequisite for their autonomous, directed movement. Phosphatidylinositol 3-kinase (PI3K) is assumed to play an important role in this polarization process, whereas the results obtained with different cell types and different migration assays widely vary. Thus, we conducted a comparative study on the ro...

Journal: :International journal of oncology 2011
Berta Pons Vicente Peg María Angeles Vázquez-Sánchez Laura López-Vicente Elisabet Argelaguet Laura Coch Alba Martínez Javier Hernández-Losa Gemma Armengol Santiago Ramon Y Cajal

Cell signaling pathways and protein translation are crucial for understanding malignant transformation. 4E-BP1 and the eIF4F complex regulate cap-dependent translation. We investigated how 4E-BP1 and eIF4E phosphorylation status affects in vitro and in vivo cell proliferation in a breast cancer model. Cells from 2 breast carcinoma lines (MDA-MB 231 and MDA-MB 468) and human fibroblasts (IMR90 c...

2016
Yuan Li Yang Wang Rui Wang Yongqiang Zhu Suli Liu Qi Wang Jiari Shao Ying Chen Liping Gao Changping Zhou Henggui Liu Xiumei Wang Huajun Zheng Jiuqing Xin

Mycoplasma mycoides subsp. mycoides is the causative agent of contagious bovine pleuropneumonia. A pathogenic strain BEN-1 was isolated from bovine lung and underwent continuous passages in rabbits for 468 generations. During this process, the strain's strong virulence became weak and, gradually, it lost the ability to confer protective immunity in cattle but developed virulence in rabbits. In ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Seung-Joo Lee Udi Qimron Charles C Richardson

The DNA helicase encoded by bacteriophage T7 consists of six identical subunits that form a ring through which the DNA passes. Binding of ssDNA is a prior step to translocation and unwinding of DNA by the helicase. Arg-493 is located at a conserved structural motif within the interior cavity of the helicase and plays an important role in DNA binding. Replacement of Arg-493 with lysine or histid...

Journal: :Journal of cell science 2017
Astrid Veß Ulrich Blache Laura Leitner Angela R M Kurz Anja Ehrenpfordt Michael Sixt Guido Posern

A change regarding the extent of adhesion - hereafter referred to as adhesion plasticity - between adhesive and less-adhesive states of mammalian cells is important for their behavior. To investigate adhesion plasticity, we have selected a stable isogenic subpopulation of human MDA-MB-468 breast carcinoma cells growing in suspension. These suspension cells are unable to re-adhere to various mat...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید