HIROYASU TSUKAGUCHI,1 STANISLAWA WEREMOWICZ,2 CYNTHIA C. MORTON,2 AND MATTHIAS A. HEDIGER2,3 1Membrane Biology Program and Renal Division, Department of Medicine, and 2Departments of Pathology and Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital and Harvard Medical School, and 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Bo...

Ning, Xue-Han, Cheng-Su Xu, and Michael A. Portman. Mitochondrial protein and HSP70 signaling after ischemia in hypothermic-adapted hearts augmented with glucose. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R11–R17, 1999.—Hypothermia improves resistance to subsequent ischemia in the cardioplegic-arrested heart (CAH). This adaptive process produces mRNA elevation for heat sho...

Champion, Hunter C., Trinity J. Bivalacqua, David G. Lambert, Rasheed A. Abassi, and Philip J. Kadowitz. Analysis of vasoconstrictor responses to histamine in the hindlimb vascular bed of the rabbit. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1179–R1187, 1999.—Hemodynamic responses to histamine were investigated in the anesthetized rabbit. Intravenous injections of histami...

Hughes, Jeremy, and Richard J. Johnson. Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction. Am. J. Physiol. 277 (Renal Physiol. 46): F26–F32, 1999.—Murine renal tubular epithelial cells and interstitial fibroblasts may express both Fas (CD95) death receptor and Fas ligand and are vulnerable to Fas-mediated death in vitro. We therefore hypothesized that a...

Shirasaka, Tetsuro, Masamitsu Nakazato, Shigeru Matsukura, Mayumi Takasaki, and Hiroshi Kannan. Sympathetic and cardiovascular actions of orexins in conscious rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1780–R1785, 1999.—The novel hypothalamic peptides orexin-A and orexin-B are known to induce feeding behavior when administered intracerebroventricularly, but little is...

Butler, Karyn L., Alice H. Huang, and Judith K. Gwathmey. AT1-receptor blockade enhances ischemic preconditioning in hypertrophied rat myocardium. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H2482–H2487, 1999.—The purpose of this study was to determine whether ischemic preconditioning protects contractile function in hypertrophied rat myocardium from ischemia-reperfusion (I/R) injury. Male s...

Arai, Andrew E., Claudia E. Kasserra, Paul R. Territo, Amir H. Gandjbakhche, and Robert S. Balaban. Myocardial oxygenation in vivo: optical spectroscopy of cytoplasmic myoglobin and mitochondrial cytochromes. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H683–H697, 1999.— The oxygenation state of myoglobin and the redox state of cytochrome c provide information on the PO2 in the cytosol and mi...

Takito, Jiro, Lunbiao Yan, Jian Ma, Chinami Hikita, S. Vijayakumar, D. Warburton, and Qais Al-Awqati. Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am. J. Physiol. 277 (Renal Physiol. 46): F277–F289, 1999.—The band 3 anion exchanger is located in the apical membrane of a b-intercalated clonal cell line, whereas the vacuolar H1ATPase ...

Itoh, Hiroaki, Jing Zheng, Ian M. Bird, Kazuwa Nakao, and Ronald R. Magness. Basic FGF decreases clearance receptor of natriuretic peptides in fetoplacental artery endothelium. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R541–R547, 1999.—Atrial natriuretic peptide (ANP) is present in the fetoplacental circulation of humans and sheep. The ANP-A receptor is the specific membra...

MICHAEL KJÆR,1 BIRGITTE HANEL,2 LARS WORM,2 GRAZYNA PERKO,2 STEVEN F. LEWIS,2 KENT SAHLIN,2 HENRIK GALBO,3 AND NIELS H. SECHER2 2Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet University Hospital; 3Department of Medical Physiology, Panum Institute; and 1Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, University of Copenhagen, DK-240...