Introduction: The aim of this study was to evaluate the sealing ability of Bioactive glass (BG) and Bioactive glass-Hydroxyapatite (BG-HA) in comparison to Mineral Trioxide Aggregate (MTA). Methods: The sealing ability of Bioactive glass and Bioactive glass-hydroxyapatite mixed with glass ionomer cement and Mineral Trioxide Aggregate used as retrograde filling material was assessed by bacterial...

This study investigated the effect of fibronectin adsorption on surface charge variations and calcium phosphate (Ca-P) layer formation kinetics on the surface of 45S5 bioactive glass (BG). We hypothesize that the adsorption of fibronectin on BG changes the surface charge and alters the kinetics of Ca-P layer formation on the glass surface. The charge at a material's surface modulates surface ch...

Background: Bioactive glasses 58S, are silicate-based materials containing calcium and phosphate, which dissolved in body fluid and bond to the bone tissue. This type of bioactive glass is highly biocompatible and has a wide range of clinical applications. Methods: The 58S glass powders were synthesized via sol-gel methods, using tetraethyl orthosilicate, triethyl phosphate, and calcium nitrate...

Bacterial infections after implant surgical procedures are a complication observed in many surgeries to treat bone injuries or diseases. Bacteria can attach the surface of producing biofilms, and if treatment with antibiotics does not work, further surgery is necessary remove infected implant. Among biomaterials for implants, bioceramics based on calcium phosphates (CaPs) such as β-TCP stand ou...

The effect of the ionic products of Bioglass 45S5 dissolution on the gene-expression profile of human osteoblasts was investigated by cDNA microarray analysis of 1,176 genes. Treatment with the ionic products of Bioglass 45S5 dissolution increased the levels of 60 transcripts twofold or more and reduced the levels of five transcripts to one-half or less than in control. Markedly up-regulated ge...

AIM To test whether bioactive glasses kill microbiota via mineralization or the release of ions other than sodium. METHODOLOGY Flame-spray synthesis was applied to produce nanometric glasses of different sodium content and constant Ca/P ratio: 28S5, 45S5 and 77S. Calcium hydroxide and nanometric tricalcium phosphate (TCP) were used as controls. Apatite induction was monitored by Raman spectro...

Herein, novel bioactive glass flakes (BGFs) (45S5 composition), obtained by compression in the liquid phase a stirred media mill, are combined with chitosan (CS) to develop composite membranes using solvent casting for guided bone regeneration (GBR). The incorporation of BGFs endows CS superior bioactivity as evidenced rapid hydroxyapatite formation after 3 days immersion simulated body fluid (...

bioactive glasses are silicate-based and can form a strong chemical bond with the tissues. these biomaterials are highly biocompatible and can form a hydroxyapatite layer when implanted in the body or soaked in the simulated body fluid. due to several disadvantages, conventional glass processing method including melting of glass components, is replaced by sol-gel method with a large number of b...