The nitrile imine-mediated tetrazole–ene cycloaddition is a widely used class of photoligation. Optimizing the reaction outcome requires detailed knowledge tetrazole photoactivation profile, which can only partially be ascertained from absorption spectroscopy, or otherwise involves laborious monitoring in solution. Photodissociation action spectroscopy (PDAS) combines advantages optical and mas...

cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...

An efficient synthesis of the angiotensin-II inhibitor valsartan (Diovan®) is presented. Directed ortho-metalation of 5-phenyl-1-trityl-1H-tetrazole (6) and its Negishi coupling with aryl bromide 5 are the key steps of the synthesis. This method overcomes many of the drawbacks associated with previously reported syntheses.

reaction of 5-phenyl tetrazole with ethyl chloroacetate to form ethyl (5-phenyl-1h-tetrazol-1-yl) acetate (1). compound 1 react with hydrazine hydrate in ethanol yield 2-(5-phenyl-1h-tetrazol-1-yl) acetohydrazide (2). the condensation of (2) with various aldehydes yield the corresponding substituted n'-[-arylidene]-2-(5-phenyl-1h-tetrazol-1-yl) acetohydrazide (3a- j). the compounds obtaine...

Abstract Nitrilium betaine 1,3-dipoles are ubiquitous reagents in organic chemistry, with applications ranging from natural product synthesis to materials science. Given the high reactivity of these zwitterionic motifs, they invariably generated situ a suitable precursor, prior use. This short review summarises recent progress development modern approaches towards formation 1,3-dipoles, and the...

cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...

cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...

To evaluate the possibility of introducing azole nucleosides as building blocks for metal-mediated base pairs in artificial oligonucleotides, imidazole nucleoside, 1,2,4-triazole nucleoside and tetrazole nucleoside have been synthesized and characterized. The X-ray crystal structures of p-toluoyl-protected 1,2,4-triazole and tetrazole nucleosides are reported. Contrary to the situation primaril...