New functionalized terphenyl derivatives incorporating various heterocyclic rings are prepared by using 4,4''-difluoro-5'-hydroxy-1,1':3',1''-terphenyl-4'-carbohydrazide as a key intermediate derived from 4,4'-difluoro chalcone, a versatile synthone. All the derivatives are characterized by (1)H NMR, IR, and mass spectral data. All the synthesized products are screened for their in vitro antimi...

A total of 19 novel (3a-3s) N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide analogs were designed, synthesized, and evaluated for biological activities as potential DNA gyrase inhibitors. The results showed that compound 3k can strongly inhibit Staphylococcus aureus DNA gyrase and Bacillus subtilis DNA gyrase (with IC50 of 0.15 µg/mL and 0.25 µg/mL, respectively). Structure-activity r...

In the Schiff base mol-ecule of the title compound, C(20)H(14)ClN(3)O(3)·CH(3)COOH·H(2)O, the central benzene ring makes dihedral angles of 36.26 (7) and 27.59 (8)°, respectively, with the terminal chloro-phenyl and pyridine rings. In the crystal, the three components are linked by O-H⋯O, N-H⋯O, O-H⋯N and C-H⋯O hydrogen bonds into a double-tape structure along the a axis.

يتضمن البحث تحضَير عدد من مشتقات6-bromo-2-phenylquinoline-4-carboxylic acid ، وقد تم تشخيصها بوساطة قياس درجة الانصهار والتحليل الكمي الدقيق للعناصر (C.H.N.S) وطيف الرنين النووي المغناطيسي للبروتون (1H-NMR) و تحليل طيف الأشعة تحت الحمراء (FT-IR) . ومن المركبات المحضرة
 1-تحضير المركب [A1] 6-bromo-2-phenylquinoline-4-carboxylic acid
 2-تحضير 6-bromo-2-phenylquinoline-4-carboxyl chloride...

The reaction of cyclopentanone with cyanoacetylhydrazine gave 2-cyano-2-cyclopentylideneacetohydrazide (1). Treatment of compound 1 with elemental sulphur in the presence of triethylamine afforded 2-amino-5,6-dihydro- -4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which in-turn formed the corresponding intermediate diazonium salt. The latter was coupled with either ethyl cyanoacetate or ethyl...