نتایج جستجو برای: 3d7 strain

تعداد نتایج: 218726  

Journal: :The Journal of organic chemistry 2013
Rohan A Davis Sandra Duffy Sabine Fletcher Vicky M Avery Ronald J Quinn

A high-throughput screening campaign using a prefractionated natural product library and an in vitro antimalarial assay identified active fractions derived from the Australian marine sponge Plakortis lita . Bioassay-guided fractionation of the CH2Cl2/CH3OH extract from P. lita resulted in the purification of four novel thiazine-derived alkaloids, thiaplakortones A-D (1-4). The chemical structur...

Journal: :The Journal of Cell Biology 1990
A P Otte D Roy M Siemerink C H Koster F Hochstenbach A Timmermans A J Durston

We characterized a novel extracellular matrix element that is present in the earliest developmental stages of Xenopus laevis, and is recognized by an mAb 3D7. Based on amino acid composition, breakdown patterns by bacterial collagenases, and the molecular weights of the components of the antigen (240, 200, and 140 kD), we found it very similar to mammalian collagen type VI. The antigen is evenl...

2014
Frances Cagayat Recuenco Kyousuke Kobayashi Akiko Ishiwa Yukiko Enomoto-Rogers Noreen Grace V. Fundador Tatsuki Sugi Hitoshi Takemae Tatsuya Iwanaga Fumi Murakoshi Haiyan Gong Atsuko Inomata Taisuke Horimoto Tadahisa Iwata Kentaro Kato

Here, we assessed the sulfated derivative of the microbial polysaccharide gellan gum and derivatives of λ and κ-carrageenans for their ability to inhibit Plasmodium falciparum 3D7 and Dd2 growth and invasion of red blood cells in vitro. Growth inhibition was assessed by means of flow cytometry after a 96-h exposure to the inhibitors and invasion inhibition was assessed by counting ring parasite...

2017
Hussein Mohammed Moges Kassa Ashenafi Assefa Mekonnen Tadesse Amha Kebede

BACKGROUND In malaria endemic regions, Plasmodium falciparum infection is characterized by extensive genetic diversity. Describing this diversity provides important information about the local malaria situation. This study was conducted to evaluate the extent of genetic diversity of P. falciparum in Pawe district, North West Ethiopia, using the highly polymorphic merozoite surface protein 2 gen...

Journal: :Molecular and biochemical parasitology 2005
Francesco Silvestrini Zbynek Bozdech Alessandra Lanfrancotti Eugenia Di Giulio Emanuele Bultrini Leonardo Picci Joseph L Derisi Elisabetta Pizzi Pietro Alano

A genome-wide expression analysis was undertaken to identify novel genes specifically activated from early stages of gametocytogenesis in Plasmodium falciparum. A comparative analysis was conducted on sexually induced cultures of reference parasite clone 3D7 and its gametocyteless derivative clone F12. Competitive hybridisations on long-oligomer microarrays representing 4488 P. falciparum genes...

2017
Jude Efiom Okokon Bassey Sunday Antia Bala Adamu Azare Patience Jude Okokon

OBJECTIVE Zea mays root decoction that has been traditionally used for the treatment of malaria by various tribes in Nigeria, was evaluated for antimalarial potential against malaria parasites using in vivo and in vitro models. MATERIALS AND METHODS The root extract of Zea mays was investigated for antimalarial activity against Plasmodium berghei in mice using rodent malaria models; suppressi...

2012
Suet C. Leung Peter Gibbons Richard Amewu Gemma L. Nixon Chandrakala Pidathala W. David Hong Bénédicte Pacorel Neil G. Berry Raman Sharma Paul A. Stocks Abhishek Srivastava Alison E. Shone Sitthivut Charoensutthivarakul Lee Taylor Olivier Berger Alison Mbekeani Alasdair Hill Nicholas E. Fisher Ashley J. Warman Giancarlo A. Biagini Stephen A. Ward Paul M. O’Neill

Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule suitable for further development. In order to reduce ClogP and improve solubility of CK-2-68 incorporation of a variety of heterocycles, within the ...

Some Dorema species are used in Persian traditional medicine. In the present study the total extract from the roots of Dorema hyrcanum Koso-Pol. was investigated for its in vitro (pLDH assay) and in vivo (Peters’ 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line MDBK (MTT test). The IC50 values for a chloroquine- sensitive (3D7) and a chl...

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