In animal tissues, NAEs (N-acylethanolamines), including N-arachidonoylethanolamine (anandamide), are primarily formed from their corresponding NAPEs (N-acylphosphatidylethanolamines) by a phosphodiesterase of the PLD (phospholipase D) type (NAPE-PLD). Recently, we cloned cDNAs of NAPE-PLD from mouse, rat and human [Okamoto, Morishita, Tsuboi, Tonai and Ueda (2004) J. Biol. Chem. 279, 5298-5305...

Desire spurs competition; here we explore whether the converse is also true. In one study, female quartets (N1⁄4 58) completed anagrams, with the winner to receive compact speakers; controls anagrammed without competition. In the other study, female quartets (N1⁄4 74) described their ideal first date to a male judge, who chose the best description; controls read to him others’ date descriptions...

The PK-LR gene was studied in 23 patients with congenital haemolytic anaemia associated with erythrocyte pyruvate kinase (PK) deficiency. Twenty-seven different mutations were detected among the 42 mutated alleles identified: 19 missense mutations, four splice site mutations and one nonsense, one single base deletion and two large deletions. Seventeen of them (107G, 278T, 403T, 409A, 661A, 859C...

To assess the role of oxidative stress and lipid peroxidation (LPO) in the pathogenesis of lung cancer, we measured the levels of 1,Nethenoadenine ( A) and 3,N-ethenocytosine ( C) in the DNA by immunoaffinity/P postlabeling (33 cases). We also measured the capacity for A and C repair (by the nicking assay) in normal and tumor lung tissues, as well as in blood leukocytes of lung cancer patients ...

In this paper, we study the method of closure games, a gametheoretic valuation method for languages of self-referential truth developed by the author. We prove two theorems which jointly establish that the method of closure games characterizes all 3and 4-valued Strong Kleene fixed points in a novel and informative manner. Amongst others, we also present closure games which induce the minimal an...

An approach to automatic detection of syllable structure is presented. We demonstrate a novel application of EM-based clustering to multivariate data, exempli ed by the induction of 3and 5-dimensional probabilistic syllable classes. The qualitative evaluation shows that the method yields phonologically meaningful syllable classes. We then propose a novel approach to grapheme-to-phoneme conversi...

The decay rate of the 2v double beta decay is calculated. The effects of pairing, static quadrupole deformation, spin-isospin polarization, and the .6.33 isobar admixtures on the nuclear matrix elements are studied and the relation of the 2v {3{3 rate and the {3and f3+ strength is stressed. In agreement with other calculations, we predict a faster decay rate than has been observed experimentall...