The SH2 domain-containing leukocyte protein of 76 kD (SLP-76) is a pivotal element of the signaling machinery controlling T cell receptor (TCR)-mediated activation. Here, we identify 14-3-3epsilon and zeta proteins as SLP-76 binding partners. This interaction was induced by TCR ligation and required phosphorylation of SLP-76 at serine 376. Ribonucleic acid interference and in vitro phosphorylat...

Latent Epstein-Barr virus (EBV) genomes are maintained in human cells as low copy number episomes that are thought to be partitioned by attachment to the cellular mitotic chromosomes through the viral EBNA1 protein. We have identified a human protein, EBP2, which interacts with the EBNA1 sequences that govern EBV partitioning. Here we show that, in mitosis, EBP2 localizes to the condensed cellu...

Far Ultraviolet Spectroscopic Explorer observations are presented for WD0621−376, a DA white dwarf star in the local interstellar medium (LISM) at a distance of about 78 pc. The data have a signal-tonoise ratio of ∼20–40 per 20 km s resolution element and cover the wavelength range 905–1187 Å. LISM absorption is detected in the lines of D I, C II, C II*, C III, N I, N II, N III, O I, Ar I, and ...

Geographical seroprevalence of Anaplasma marginale(T) in sheep, Ovis aries (L) was done from January-May, 2012 in district Peshawar which is a crowded area of Pakistan. In this area sheep’s infection with A. marginale is not reported before. For this purpose, 376 serum samples were obtained conveniently from 4 different breeds of sheep, from different geographical areas of Peshawar. An indirect...

Chapter Outline Introduction 371 Epigenetics and Behavioral Biology 374 Epigenotypes Versus Epiphenotypes (Molecular vs. Molar Epigenetics) 375 The Epigenotype or Molecular Epigenetics 375 The Epiphenotype or Molar Epigenetics 376 Context-Dependent vs. Germline-Dependent Epigenetic Modifications 376 Context-Dependent Epigenetic Modification 377 Germline-Dependent Epigenetic Modification 378 Tra...

Introduction ..................................................................................................................... 359 I. Voting Rights Act, Section 2: Minority Voting Dilution and Protection of Communities of Common Interest ............................................................ 362 II. Democratic Inclusion and Demographic Diversity ..........................................

Tuberculosis is one of the main causes of death worldwide. This study aimed to determine predictive factors for death in patients with tuberculosis to set priorities for public heath interventions to reduce mortality in these patients. This nested case-control study was carried out in Mazandaran province of Islamic Republic of Iran among tuberculosis patients who were treated during 2002-2009. ...

Chapter Outline Introduction 371 Epigenetics and Behavioral Biology 374 Epigenotypes Versus Epiphenotypes (Molecular vs. Molar Epigenetics) 375 The Epigenotype or Molecular Epigenetics 375 The Epiphenotype or Molar Epigenetics 376 Context-Dependent vs. Germline-Dependent Epigenetic Modifications 376 Context-Dependent Epigenetic Modification 377 Germline-Dependent Epigenetic Modification 378 Tra...

Ionizing radiation (IR) induces an increase in the levels and activity of the p53 tumor suppressor protein. The increased activity is attributed to IR-induced posttranslational modifications, some of which regulate the interaction of p53 with other proteins. One of these modifications is dephosphorylation of Ser(376), which leads to association of p53 with 14-3-3 proteins. To establish the sign...

clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): April 18, 2013 www.sciencemag.org (this information is current as of The following resources related to this article are avail...