نتایج جستجو برای: 375

تعداد نتایج: 6827  

Journal: :Archives of Cardiovascular Diseases Supplements 2012

Journal: :Acta poloniae pharmaceutica 2012
Ewa Chodurek Magdalena Zdybel Barbara Pilawa Zofia Dzierzewicz

Drug binding by melanin biopolymers influence the effectiveness of the chemotherapy, radiotherapy and photodynamic therapy. Free radicals of melanins take part in formation of their complex with drugs. The aim of this work was to determine the effect of the two compounds: valproic acid (VPA) and cisplatin (CPT) on free radicals properties of melanin isolated from A-375 melanoma cells. Free radi...

2014
Qifang Tian Yang Li Fenfen Wang Ying Li Junfen Xu Yuanming Shen Feng Ye Xinyu Wang Xiaodong Cheng Yaxia Chen Xiaoyun Wan Weiguo Lu Xing Xie

BACKGROUND Papanicolaou (Pap) triage, with high specificity, has been recommended for primary Human papillomavirus (HPV) testing but is flawed by poor sensitivity and cytologist dependence. We evaluated the potential role of microRNA (miRNA) detection in cervical exfoliated cells in HPV-positive women from a clinic-based population. METHODS Primary HPV testing as well as Pap test were perform...

Journal: :Molecular cancer research : MCR 2014
Martin Hart Elke Nolte Sven Wach Jaroslaw Szczyrba Helge Taubert Tilman T Rau Arndt Hartmann Friedrich A Grässer Bernd Wullich

UNLABELLED MicroRNAs (miRNA) posttranscriptionally regulate gene expression and are important in tumorigenesis. Previous deep sequencing identified the miRNA profile of prostate carcinoma versus nonmalignant prostate tissue. Here, we generated miRNA expression profiles of prostate carcinoma by deep sequencing, with increasing tumor stage relative to corresponding nonmalignant and healthy prosta...

2014
Lise Lotte Christensen Anja Holm Juha Rantala Olli Kallioniemi Mads H. Rasmussen Marie S. Ostenfeld Frederik Dagnaes-Hansen Bodil Øster Troels Schepeler Heidi Tobiasen Kasper Thorsen Oliver M. Sieber Peter Gibbs Philippe Lamy Torben F. Hansen Anders Jakobsen Eva M. Riising Kristian Helin Jan Lubinski Rikke Hagemann-Madsen Søren Laurberg Torben F. Ørntoft Claus L. Andersen

MicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed in human cancers. Particular miRNAs function either as tumor suppressors or oncogenes and appear to have diagnostic and prognostic significance. Although numerous miRNAs are dys-regulated in colorectal cancer (CRC) only a small fraction has been characterized functionally. Using high-throughput fun...

2016
Binbing Ling Deborah Michel Meena Kishore Sakharkar Jian Yang

Malignant melanoma (MM) is the most dangerous type of skin cancer, killing more than 1,100 people each year in Canada. Prognosis for late stage and recurrent MM is extremely poor due to insensitivity to chemotherapy drugs, and thus many patients seek complementary and alternative medicines. In this study, we examined four commonly used anticancer herbs in traditional Chinese medicine, Hedyotis ...

2012
Ming-Yu Yang Pai-Mei Lin Yi-Chang Liu Hui-Hua Hsiao Wen-Chi Yang Jui-Feng Hsu Cheng-Ming Hsu Sheng-Fung Lin

BACKGROUND Cellular senescence is a specialized form of growth arrest that is generally irreversible. Upregulated p16, p53, and p21 expression and silencing of E2F target genes have been characterized to promote the establishment of senescence. It can be further aided by the transcriptional repression of proliferation-associated genes by the action of HP1γ, HMGA, and DNMT proteins to produce a ...

Journal: :World Allergy Organization Journal 2012

2006
Satoshi Kobori Yu Masuda Manabu Horii Wataru Marubashi

In Nicotiana suaveolens N. tabacum hybrid cells incubated with high levels (0.8, 4.0 or 20 mM) of BAP at 28°C, the percentage of dead cells and extent of nuclear fragmentation were suppressed and some cultured cells remained green compared with those incubated with a standard level (0.04 mM) of BAP. Though DNA ladders were detected in all hybrid cells incubated at 28°C, positive signals for TUN...

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