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The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted activation of three ER stress sensors, namely IRE1, PERK and ATF6. Global approaches in several cellular contexts have revealed that UPR regulates the expression of many miRNAs tha...

INTRODUCTION Keratoacanthoma is a fast-growing crateriform skin tumor. Approximately 25% of such tumors undergo malignant transformation and develop areas of squamous cell carcinoma (SCC). The presence of laminin-322 has been associated with progression to invasive forms of SCC. The aim of this study was to determine whether or not immunohistochemical staining for laminin-322 would be of value ...

n0 = min{n ∈ N | f(n) > n + 1}, then the proof of Kahn and Kalai gives n0 ≤ 1325. On the other hand we know only that n0 ≥ 4 (Perkal [7]; Eggleston [3]). It is of interest where n0 lies. The upper bound on n0 was improved to n0 ≤ 946 (Nilli [6]), n0 ≤ 561 (Raigorodski [8]), n0 ≤ 560 (Weißbach [9]), and n0 ≤ 323 (Hinrichs [4]). In fact, we know that f(n) > n + 1 for all n ≥ 323. Here we show tha...

OBJECTIVES New antimicrobials are essential to prevent gonorrhoea becoming an untreatable infection. Herein, the in vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against Neisseria gonorrhoeae strains were investigated and compared with antimicrobials currently or previously recommended for treatment of gonorrhoea. METHODS MICs (mg/L) were ...

A 1314 nm Nd:YLF laser was designed and operated both CW and passively Q-switched. Maximum CW output of 10.4 W resulted from 45.2 W of incident pump power. Passive Q-switching was obtained by inserting a V:YAG saturable absorber in the cavity. The oscillator delivered a maximum of 825 μJ energy per pulse, with a pulse duration of 135 ns at a pulse repetition frequency of 6.3 kHz, effectively de...