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Background Inhibitors of tumor necrosis factor-alpha (TNFi) are central to management rheumatoid arthritis (RA) though continued use beyond initial failure is negatively associated with response subsequent TNFi treatment. Objectives To assess the patterns recurrent relative reasons for switch as observed in community rheumatology care US. Methods Data: PIONEER-Rheumatology, an EMR and open text...

Clopidogrel, an adenosine biphosphate receptor antagonist, inhibits platelet aggregation and is widely used to prevent thrombotic complications of atherosclerosis or after percutaneous coronary stent placement. Various studies have shown that clopidogrel is as safe as aspirin and better tolerated than ticlopidine.1,2 The most common adverse effects are gastrointestinal discomfort, exanthema, an...

BACKGROUND Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. A widely practicable treatment that reduces blood loss after trauma could prevent thousands of premature deaths each year. The CRASH-2 trial aimed to determine the effect of the early administration of tranexamic acid on death and transfusion requirement in bleeding trauma patients. In add...

The high infrared quantum yield, continuous absorption spectrum, and band edge tunability of colloidal quantum dots (QD) has opened up new opportunities to use luminescent down shifting for multispectral imaging in the infrared. We demonstrate a QD sensitized short wavelength infrared (SWIR) camera which is capable of UV-SWIR multispectral imaging. The application of multispectral cameras for U...

The purpose of this study was to investigate long-term outcomes simultaneous carotid endarterectomy (CEA) and coronary artery bypass (CABG) using the Vascular Quality Initiative. All CEAs in Initiative between January 2003 May 2022 were queried. We extracted two cohorts from these CEAs. first group underwent CEA CABG (N = 3137). second or percutaneous angioplasty/stent within 5 years 27,387). i...

Nerve infiltration into the tumor is a common feature of microenvironment. The mechanisms axonogenesis in breast cancer remain unclear. We hypothesized that vascular endothelial growth factor (VEGF), as well nerve (NGF), involved cancer. A N-methyl-N-nitrosourea (MNU)-induced rat model was used to explore presence and involvement VEGF, NGF, tumor. found MNU-induced including sensory sympathetic...

•m-SiO2-PEG shows less destruction to the vascular system than f-SiO2•m-SiO2-PEG intravasation and extravasation prevents cancer cells from migrating upon intracellular endocytosis The fast-growing investigations of mesoporous silica (m-SiO2) have been offering great opportunities for nanomedicine. Recently, highly agglomerated fumed (f-SiO2) sintered by elevated temperatures without any surfac...

Open AccessCCS ChemistryRESEARCH ARTICLE1 Jul 2021Asymmetric Spirocyclization Enabled by Iridium and Brønsted Acid-Catalyzed Formal Reductive Cycloaddition Nan-Fang Mo†, Le Yu†, Ying Zhang, Ya-Hong Yao, Xun Kou, Zhi-Hui Ren Zheng-Hui Guan Mo† Key Laboratory of Synthetic Natural Functional Molecule Ministry Education, Department Chemistry & Materials Science, Northwest University, Xi’an 710127 †...