INTRODUCTION Soft-tissue sarcomas account for 0.7% of all malignant tumors, with an incidence rate of 3 per 100,000 persons/year. The undifferentiated pleomorphic sarcoma (UPS) with giant cells, a high grade tumor of soft tissue, is very unusual, especially in young adults before the age of 40. Human T-cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus, classified as group 1 human ca...

Regulated turnover of proteins in the cytosol and nucleus of eukaryotic cells is primarily performed by the ubiquitin-proteasome system (UPS). The UPS is involved in many essential cellular processes. Alterations in this proteolytic system are associated with a variety of human pathologies, such as neurodegenerative diseases, cancer, immunological disorders and inflammation. The precise role of...

A major challenge to broadening oncology applications for inhibitors of the ubiquitin-proteasome system (UPS) is the identification of UPS-dependent cancer pathways predictive of tumors responsive to peptidomimetic inhibitors of its 20S core protease activity. To inform clinical studies evaluating UPS inhibitors as breast cancer therapeutics, seven phenotypically diverse human breast cancer cel...

Rotating disks with nonzero radial pressure and finite radius are studied. The models are based in the Taub-NUT metric and constructed using the well-known “displace, cut and reflect” method. We find that the disks are made of perfect fluids with constant energy density and pressure. The energy density is negative, but the effective Newotnian density is possitive as the strong energy condition ...

The coconut mite, Aceria guerreronis Keifer, has emerged as a common menace to most of the coconut plantations in India. After its first upsurge in Kerala at the end of the 1990 ́s, the mite has spread to many states in southern and northern India, causing considerable damage. Coconut provides one third of the agricultural income in the regions in which it is grown and more than 10 million peopl...

ALE and Taub-NUT (or ALF) hyper-Kahler four-manifolds can be naturally constructed as hyper-Kahler quotients. In the ALE case, this construction has long been understood in terms of D-branes; here we give a D-brane derivation in the Taub-NUT case. Likewise, instantons on ALE spaces and on Taub-NUT spaces have ADHM-like constructions related to hyper-Kahler quotients. Here we refine the analysis...