This study sought to assess the prognostic significance of the degree of extranodal extension (ENE) and several other risk factors in pathological ENE penile carcinoma. We analyzed prospectively collected data on a consecutive series of 31 chemotherapy-naive patients with proven ENE who underwent therapeutic regional lymphadenectomy. Postoperative external radiotherapy was then performed. We st...

The anaerobic metabolism of phthalate and other aromatic compounds by the denitrifying bacterium Pseudomonas sp. strain P136 was studied. Benzoate, cyclohex-1-ene-carboxylate, 2-hydroxycyclohexanecarboxylate, and pimelate were detected as predominant metabolic intermediates during the metabolism of three isomers of phthalate, m-hydroxybenzoate, p-hydroxybenzoate, and cyclohex-3-ene-carboxylate....

Hydroboration of propyne and 1-butyne with HBCl2 obtained from BCl3 and Me3SiH in equimolar amounts leads to 1,1-bis(dichloroboryl)alkanes 1. When BCl3 is used in excess, no 1,1-bis(dichloroboryl)alkanes 1 but E-1-dichloroborylalkene 2 besides E-1-dichloroboryl-2chloro-alk-1-ene 3 are formed. Other by-products are tris(2-chloro-alk-1-ene-1-yl)borane 4 and bis(2-chloro-alk-1-ene-1-yl)chloroboran...

(S)-4,4-Dichloro-3-methylbutanoic acid was prepared in 51% overall yield from commercially available starting materials using an organocatalytic transfer hydrogenation to 4,4-dichloro-3-methylbut-2-enal in the key step. The (S)-dichloro acid was used as an intermediate in the first total synthesis of dysideaproline E and a diastereomer confirming the structure of the natural product.

We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4''-nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate produc...

The hydrophosphination reaction of 1,3-butadiene in the presence of Cp(2)EuH has been studied by DFT methods. It has been possible to show that such a reaction can be catalytically performed and that the active species is Cp(2)EuPH(2). The phosphido complex can be formed from the hydride either in a one step reaction (direct P-H activation in the presence of Cp(2)EuH) or in a two-step reaction ...