The neutron therapy facility at the Gershenson Radiation Oncology Center, Harper University Hospital in Detroit has been operational since September 1991. The d(48.5)+Be beam is produced in a gantry mounted superconducting cyclotron designed and built at the National Superconducting Cyclotron Laboratory (NSCL). Measurements were performed in order to obtain the physical characteristics of the n...

Physiologically based pharmacokinetic modeling provides important capabilities for improving the reliability of the extrapolations across dose, species, and exposure route that are generally required in chemical risk assessment regardless of the toxic end point being considered. Recently, there has been an increasing focus on harmonization of the cancer and noncancer risk assessment approaches ...

BACKGROUND Megavoltage beams used in radiotherapy are contaminated with secondary electrons. Different parts of linac head and air above patient act as a source of this contamination. This contamination can increase damage to skin and subcutaneous tissue during radiotherapy. Monte Carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in optim...

PURPOSE To present the results and discuss potential insights gained through surveys on reference dosimetry practices. METHODS Two surveys were sent to medical physicists to learn about the current state of reference dosimetry practices at radiation oncology clinics worldwide. A short survey designed to maximize response rate was made publicly available and distributed via the AAPM website an...

Some of the more relevant recent achievements and developments in the field of external radiation dosimetry are reviewed in this presentation. Among them, topics related to personal dosimetry, as the relative role of active and passive methods and the features of some recently proposed new methods. Electronic personal dosemeters and Optically Stimulated Luminescence, OSL, have already accredite...

Lithium formate has shown to be a material with properties suitable for electron paramagnetic resonance (EPR) dosimetry, among them up to 7 times higher sensitivity compared to alanine, which is a well-established EPR detector material for dose determinations in radiotherapy. The aim of this thesis was to further investigate the properties of lithium formate and develop the dosimetry system tow...

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Background All randomised phase 3 studies of selective internal radiation therapy for advanced hepatocellular carcinoma published to date have reported negative results. However, these did not use personalised dosimetry. We aimed compare the efficacy a versus standard dosimetry approach with yttrium-90-loaded glass microspheres in patients carcinoma. Methods DOSISPHERE-01 was randomised, multic...

Radiotherapy, more then any other treatment modality, relies heavily and often exclusively on medical imaging to determine the extent of disease and the spatial relation between target region and neighbouring healthy tissues. Radically new approaches to radiation delivery are inspired on CT scanning and treat patients in a slice-by-slice fashion using intensity modulated megavoltage fan beams. ...