quantitative structure-activity relationship (qsar) studies of a series of substituted 3-hydroxy-pyridine-4-ones and 3-hydroxy-pyran-4-ones as antibacterial and antifungal agents against a variety of microorganisms were performed. multiple linear regression approach was used as variable selection method. the antimicrobial activities of these compounds against staphylococcus aureus, aspergilus n...

5-fluorouracil (5-FU) and its prodrug capecitabine are Fluoropyrimidines, widely used in colorectal cancer. The prevention of adverse effects related to severe toxicity Fluoropyrimidines essentially involves pre-therapeutic screening for dihydropyrimidine dehydrogenase (DPD) deficiency, which must be carried out systematically before starting treatment with fluorouracil or since the joint HAS/I...