In the present study, we evaluated the antitumor effect of two synthetic analogs of vitamin D, namely PRI-2191 [(24R)-1,24-dihydroxyvitamin D3] and PRI-2205 (5,6-trans calcipotriol), in combined human colon HT-29 cancer treatment with 5-fluorouracil (5-FU). Mice bearing HT-29 tumors transplanted subcutaneously or orthotopically were injected with vitamin D analogs and 5-FU in various schedules....

Japanese 0.937 (0.653–1.343) .791 0.650 (0.275–1.538) .426 1.031 (0.645–1.648) .995 I/I 45 (47.4) 128 (48.1) I/D 43 (45.3) 109 (41.0) D/D 7 (7.4) 29 (10.9) I 133 (70.0) 365 (68.6) D 57 (30.0) 167 (31.4) Indian 0.907 (0.637–1.291) .651 1.215 (0.425–3.473) .796 0.853 (0.569–1.281) .508 I/I 181 (72.1) 139 (68.8) I/D 61 (24.3) 57 (28.2) D/D 9 (3.6) 6 (3.0) I 423 (84.3) 335 (82.9) D 79 (15.7) 69 (17.1)

BACKGROUND Nutritional rickets is a growing global public health concern despite existing prevention programmes and health policies. We aimed to compare infant and childhood vitamin D supplementation policies, implementation strategies and practices across Europe and explore factors influencing adherence. METHODS European Society for Paediatric Endocrinology Bone and Growth Plate Working Grou...

a Epilepsy Monitoring Unit, Department of Neurology, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain b Epilepsy Monitoring Unit, Pediatric Department, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain c Electrophysiology Unit, Department of Cardiology, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, Spain d IMIM (Hospital del Mar Medical Research Institut...

Background: Approximately 600,000 deaths occur every year as a result of the acute and chronic consequences of hepatitis B virus infection. Ten different hepatitis B virus genotypes have been identified with distinct geographical distributions. Different clinical outcomes, including the rate of mutations, development of hepatocellular carcinoma, chronicity, response to treatment, transplantatio...

Contents Chapter 1. Introduction 7 1. Historical sketch 7 a. Homoclinic tangles 7 b. Geodesic flows 8 c. Picking up from Poincaré 8 d. Modern hyperbolic dynamics 9 e. The slowness of the initial development 9 2. Hyperbolic dynamics 10 3. Outline of this survey 10 a. Regularity 11 Chapter 2. Hyperbolic sets and stable manifolds 13 1. Definitions and examples 13 a. Hyperbolic linear maps, adapted...