Rapid eye movement (REM) sleep dysregulation is a symptom of many neuropsychiatric disorders, yet the mechanisms of REM sleep homeostatic regulation are not fully understood. We have shown that, after REM sleep deprivation, the pedunculopontine tegmental nucleus (PPT) plays a critical role in the generation of recovery REM sleep. In this study, we used multidisciplinary techniques to show a cau...

Scylla paramamosain is a euryhaline marine crab that can actively regulate its osmotic pressure of the hemolymph. We investigated the expression of Na,K-ATPase in the osmoregulatory organs, including anterior gills, posterior gills, antennal glands, and midgut. Our cDNA sequencing of the Na,K-ATPase alpha-subunit revealed no isoforms in any of the four osmoregulatory organs studied. The full-le...

Van Dort et al. (1) used optogenetic activation to demonstrate the capacity of cholinergic neurons in the laterodorsal and pedunculopontine tegmental nuclei (LDT and PPT, respectively) to induce rapid eye movement (REM) sleep. The authors submit that their data clarify the role of LDT/PPT cholinergic neurons in REM sleep initiation, demonstrating that these neurons are “important modulators of ...

Hemolymph osmolality, and changes in gill carbonic anhydrase (CA) activity, relative mRNA expression, and CA protein concentration were measured in the green crab Carcinus maenas acclimated to 32 ppt salinity and transferred to 10 ppt. Hemolymph osomolality stabilized at new, acclimated values, by 24 hr after transfer. There was a large increase in CA mRNA concentrations, as measured by quantit...

Acetylation of small molecules is widespread in nature, and in some cases, cells use this process to detoxify harmful chemicals. Streptomyces species utilize a Gcn5 N-acetyltransferase (GNAT), known as Bar, to acetylate and detoxify a self-produced toxin, phosphinothricin (PPT), a glutamate analogue. Bar homologues, such as MddA from Salmonella enterica, acetylate methionine analogues such as m...

Triptolide (TP) displays a strong immunosuppression function in immune-mediated diseases, especially in the treatment of rheumatoid arthritis. However, in addition to its medical and health-related functions, TP also exhibits diverse pharmacological side effects, for instance, liver and kidney toxicity and myelosuppression. In order to reduce the side effects, a nano drug carrier system (γ-PGA-...

Hemolysis is the most common reason why coagulation test samples are rejected. However, the effects of hemolysis on plasma prothrombin time (PPT) and activated partial thromboplastin time (APTT) are rarely investigated and the results are controversial. This research aims to analyze the effects of hemolysis on PPT and APPT using the photo-optical method.Nonhemolyzed citrate blood samples (n = 3...

• What is the purpose of summarising the project in a poster format? • What size paper should the poster be? • How big should the text be? • What sort of information should be included? • Where can I get the poster printed off? • What will happen at the poster session? • Does the poster count towards the degree grade? • Will I be given guidance in preparing the poster? • Can I use my poster aga...

Interconnect Component MEM T2 HDS API Transaction Accurate Architecture T2 T3 Comm OS HAL API HDS API SystemC TLM Interconnect Component (Bus/NoC) CPU-SS1 Abstract CPU1 Periph Interface Memory Abstract CPU2 Periph Interface Memory CPU-SS2 MEM-SS T2 HDS API Comm OS HAL API T3 HAL Virtual Prototype SystemC TLM CPU-SS1 CPU1 ISS Periph Interface Memory CPU2 ISS Periph Interface Memory CPU-SS2 Inter...

Masih adanya kultur budaya patriarki di masyarakat yang memposisikan laki – sebagai superior dan perempuan subordinat menjadikan perilaku diskrimasi, ekploitas serta kekerasan terhadap masih terjadi. Data Catatan Tahunan Komnas Perempuan Tahun 2020 menyatakan bahwa dalam kurun waktu 12 tahun, meningkat sebanyak 792% (hampir 800%) artinya Indonesia tahun terakhir 8 kali lipat. Kementerian Pember...