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ion, using a notion of re nement instead of bisimulation. In this paper we adopt the rst approach, using a timed process algebra for representing designs, and relying on model-checking (or at least hand veri cation of timed logic speci cations) as our proof method. Having said that, there is a large literature on timed logics and proof techniques (including modelchecking) [21, 22, 23, 24, 25, 1...
18 Glucocorticoids and FoxO3 exert similar metabolic effects in skeletal muscle. FoxO3 19 gene expression was increased by dexamethasone (Dex), a synthetic glucocorticoid, both in vitro 20 and in vivo. In C2C12 myotubes the increased expression is due to, at least in part, the elevated 21 rate of FoxO3 gene transcription. In the mouse FoxO3 gene, we identified three glucocorticoid 22 receptor (...
Early adversity, for example poor caregiving, can have profound effects on emotional development. Orphanage rearing, even in the best circumstances, lies outside of the bounds of a species-typical caregiving environment. The long-term effects of this early adversity on the neurobiological development associated with socio-emotional behaviors are not well understood. Seventy-eight children, who ...
In addition to the classical nuclear receptor pathway, there is a non-genomic pathway in the cell membrane that regulates gene expression in animal steroid hormone signaling; however, this mechanism is unclear. Here, we report that the insect steroid hormone 20-hydroxyecdysone (20E) regulates calcium influx via phospholipase C gamma 1 (PLCG1) to modulate the protein kinase C (PKC) phosphorylati...
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