When an organism responds for a reward, its learned behavior can be characterized as goal-directed or habitual based on whether or not it is susceptible to reward devaluation. Here, we evaluated whether instrumental responding for brain stimulation reward (BSR) can be devalued using a paradigm traditionally used for natural rewards. Rats were trained to lever press for BSR; afterward, BSR was p...

Purpose Goal setting is an essential rehabilitation activity. However, multidisciplinary staff goal-setting practice with stroke survivors aphasia and associated training needs are not well understood.Methods We designed, piloted, conducted a survey of in the UK, Australia, Aotearoa New Zealand, Canada, Ireland. Analysis included descriptive statistics, chi-square Fisher’s exact tests, qualitat...

_________________________________________________________________________________________________ *Correspondence: Gert Storm Tel: +31 30 253 7306; Fax: +31 30 251 7839; E-mail: [email protected]

Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, People’s Republic of China; Department of Biochemistry, Changzhi Medical College, Changzhi, Shanxi 046000, People’s Republic of China; Department of Medical Bioinformatics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, ...

Citation: Cumming BF, Laird KR, Gregory-Eaves I, Simpson KG, Sokal MA, Nordin RN and Walker IR (2015) Tracking past changes in lake-water phosphorus with a 251-lake calibration dataset in British Columbia: tool development and application in a multiproxy assessment of eutrophication and recovery in Osoyoos Lake, a transboundary lake in Western North America. Front. Ecol. Evol. 3:84. doi: 10.338...

Previous studies have shown that binding sites for fibrinogen on platelets stimulated with platelet-activating factor (PAF), adenosine diphosphate or epinephrine rapidly close in the absence of fibrinogen. In the present study we investigated whether a-thrombin induced similar changes in the glycoprotein (GP) IIB/IIIA-complex. Whereas 80% of binding sites exposed by PAF closed within 30 minutes...

I read the recently published article in Vol 6 (3) of Basic and Clinical Neuroscience entitled “Study the Effect of Endocannabinoid System on Rat Behavior in Elevated PlusMaze” by Komaki et al. (2015). In this valuable article, the authors uncovered the effects of AM251 as a CB1 receptor antagonist on anxiety-like behaviors of rats using elevated plus-maze. However, I have a few comments on thi...

This study investigated the participation of the hypothalamic endocannabinoid system in the response to lipopolysaccharide (LPS) challenge evaluating oxytocin (OXT) and tumor necrosis factor-alpha (TNF-alpha) plasma levels in vivo and their release from hypothalamic fragments in vitro. LPS increased OXT and TNF-alpha release through anandamide-activation of hypothalamic cannabinoid receptor CB(...

Cannabinoid type 1 Receptor (CB1) belongs to the GPCR family and it has been targeted, so far, for the discovery of drugs aimed at the treatment of neuropathic pain, nausea, vomit, and food intake disorders. Here, we present the development of the first fluorescent assay enabling the measurement of kinetic binding constants for CB1 orthosteric ligands. The assay is based on the use of T1117, a ...

At Eurocrypt ’06, Nguyen and Regev presented a new key-recovery attack on the GoldreichGoldwasser-Halevi (GGH) lattice-based signature scheme: when applied to NTRUSign-251 without perturbation, the attack recovers the secret key given only 90,000 signatures. At the rump session, Whyte speculated whether the number of required signatures might be significantly decreased to say 1,000, due to the ...