INTRODUCTION The F3 peptide (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK), a fragment of the human high mobility group protein 2, binds nucleolin. Nucleolin is expressed in the nuclei of normal cells but is also expressed on the membrane of some cancer cells. The goal was to investigate the use of 111In-labeled F3 peptide for Auger electron-targeted radiotherapy. METHODS F3 was labeled with fluorescein i...

PREFATORY NOTE........................................................ 228 INTRODUCTION.................................................................................. 229 RESEARCH ON TRANSFORMATION................................................................ 229 Strains....................................................................................... 230 Media...........................

Correspondence Z. A. Efstathiadou, PhD Consultant Endocrinologist Department of Endocrinology “Hippokration” General Hospital of Thessaloniki Konstantinoupoleos 49 54642 Thessaloniki Greece Tel.: + 30/231/3312 269 Fax: + 30/231/0532 372 [email protected]

Few data are available about the prevalence of Salmonella enterica serovar Enteritidis (S.E.) and Typhimurium (S.T.) in ornamental poultry Italy. The aim this study was to investigate seroprevalence for S.E. S.T. using serological tests spp. eggs by culture methods. For purpose, 240 serum samples 216 were sampled from asymptomatic unvaccinated hens reared 24 farms, located 8 different Italian r...

objective(s): the janus kinase-signal transducers and activators of transcription signaling pathway (jak/stat pathway) play an important role in proliferation of breast cancer cells. previous data showed that inhibition of stat3 suppresses the growth of breast cancer cells, but the associated mechanisms are not well understood. this study aims to investigate the effect and associated mechanisms...

Treatment of WEHI 231 immature B-lymphoma cells with an antibody against their surface immunoglobulin (anti-Ig) induces apoptosis and has been studied extensively as a model of B-cell tolerance. Anti-Ig treatment of exponentially growing WEHI 231 cells results in an early transient increase in c-myc expression that is followed by a decline to below basal levels; this decrease in c-myc expressio...

Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not only reduce osteolysis associated with metastatic breast cancer, but also decrea...

Autophagy, an important homeostatic cellular recycling mechanism, has emerged as a novel cytoprotective mechanism to increase tumor cell survival through escaping chemotherapy‑induced cell death. To explore whether autophagy plays a protective role in the resistance to the tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL), we evaluated the autophagy levels in TRAIL‑sensitive MDA‑M...

We have shown previously that withaferin A (WA), a promising anticancer constituent of Ayurvedic medicine plant Withania somnifera, inhibits growth of human breast cancer cells in culture and in vivo in association with apoptosis induction. The present study builds on these observations and demonstrates that WA inhibits constitutive as well as interleukin-6 (IL-6)-inducible activation of signal...