BACKGROUND Aflatoxin B1 (AFB1) is potent hepatotoxic and hepatocarcinogenic agent. In aflatoxicosis, oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage. The aim of this work was to evaluate the hepatoprotective effect of cactus cladode extract (CCE) on aflatoxin B1-induced liver damage in mice by measuring malondialdehyde (MDA) level, the protein...

BACKGROUND Aflatoxin B1 (AFB1), produced by Aspergillus flavus, is one of the most life threatening food contaminants causing significant economic losses worldwide. Biological AFB1 degradation by microorganisms, or preferably microbial enzymes, is considered as one of the most promising approaches. OBJECTIVES The current work aimed to study the AFB1-degrading metabolites, produced by Phoma gl...

The binding characterization of aflatoxins with calf thymus DNA (ctDNA) under physiological conditions was investigated. Multispectroscopic techniques, ctDNA melting, viscosity measurements, and molecular docking techniques were employed to elucidate the binding mechanism of the aflatoxins with DNA. The fluorescence results indicated that both aflatoxin B1 (AFB1) and aflatoxin G1 (AFG1) bound t...

Infection with hepadnaviruses and exposure to aflatoxin B1 (AFB1) are considered major risk factors in the development of hepatocellular carcinoma (HCC) in humans and in animals. A high rate of mutations in the p53 tumor suppressor gene in hepatocellular carcinomas of predominantly hepatitis B virus (HBV) carrier patients has been recently related to dietary aflatoxin. Another member of the hep...

Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, sup...

The presence of fungi and aflatoxin B1 (AFB1) in 101 animal feed samples randomly collected from different vendors factories Algeria was investigated. For fungi, the main genera isolated were Aspergillus, Penicillium Fusarium. Furthermore, 459 strains Aspergillus section Flavi screened for their ability to produce aflatoxins cyclopiazonic acid (CPA). 49% produced AFB1 while 74.5% producers. hig...

 In the present study, the impacts of various concentrations of Aflatoxin B1 (AFB1) on Beluga, Huso huso, under controlled conditions were investigated. Belugas (120±10g) were fed on diets containing 0, 25, 50, 75, and 100 ppb AFB1/kg of diet for 3 months. Results showed various levels of AFB1 do not significantly affect the specific growth ratio (SGR) (P<0.05) of fish in different treatments. ...

this study was conducted to investigate the effect of aflatoxin b1 (afb1) on performance and egg quality in broiler breeders and the abatement of its deteriorative effect through its counteraction with herbal mycotoxin binder (hmb). thirty-six, 28-wk-old broiler breeder hens were allotted to one of the three treatments of: (1) basal diet (control),(2) control plus 500 μg kg-1 afb1 and (3) contr...

A variety of moulds routinely infect the world’s cereal crops. Under certain field or storage conditions, some moulds can produce toxin metabolites “mycotoxins“. Aflatoxins (AFs) are a group of highly carcinogenic mycotoxins produced primarily by the fungus Aspergillus flavus. Within the group of AFs, Aflatoxin B1 (AFB1) have been reported to be carcinogenic, teratogenic, tremorgenic, and derma...