The size of endocytic clathrin-coated vesicles (CCVs) is remarkably uniform, suggesting that it is optimized to achieve the appropriate levels of cargo and lipid internalization. The three most abundant proteins in mammalian endocytic CCVs are clathrin and the two cargo-selecting, clathrin adaptors, CALM and AP2. Here we demonstrate that depletion of CALM causes a substantial increase in the ra...

Changes in gene and genotypic frequencies at four esterase loci were monitored over 25 generations in Composite Cross V, an experimental population of barley, to obtain experimental evidence concerning the balance of forces responsible for: (1) the marked differences in allelic frequencies among barleys from different ecogeographical regions of the world; and (2) the extensive allelic variation...

Abstract A combined numerical and experimental investigation is carried out to analyze the cycle-to-cycle variations (CCV) in an optically accessible spark-ignition engine with port fuel injection. stable unstable operating condition considered. Well-established turbulence, combustion, ignition models are employed large-eddy simulations (LES). High-speed measurements of velocity field via parti...

The inability to identify natal origins (i.e., individual rivers and hatcheries) of adult Pacific salmon in the ocean has impeded our understanding of their ocean ecology and the management of mixed-stock fisheries. Strontium isotope (87Sr : 86Sr) ratios recorded in otoliths of fall-run Chinook salmon (Oncorhynchus tshawytscha) from all major natural and hatchery spawning sites in the Californi...

Clathrin-coated vesicles (CCV) mediate protein sorting and vesicular trafficking from the plasma membrane and the trans-Golgi network. Before delivery of the vesicle contents to the target organelles, the coat components, clathrin and adaptor protein complexes (APs), must be released. Previous work has established that hsc70/the uncoating ATPase mediates clathrin release in vitro without the re...

Cette étude examine comment procèdent les enfants en situation d’écriture inventée, lors d’une même passation, considérant tant le nombre de lettres produites pour chaque mot que unités orales auxquelles ces correspondent. À l’encontre l’hypothèse courante selon laquelle procèderaient à un moment donné façon unitaire (par exemple syllabique ou phonémique) et uniforme (quel soit l’objet écrire),...

BACKGROUND & OBJECTIVE ADHD is one of the most common mental disorders among children. We hypothesized that ADHD is associated with the impairment of the cardiac autonomic regulation. The aim of this study was to evaluate the cardiac autonomic regulation in children with ADHD at the rest and during orthostasis using short-term heart rate variability (HRV) analysis. METHODS Eighteen children w...

PURPOSE The diagnosis and monitoring of liver fibrosis is an important clinical issue; however, this is usually achieved by invasive methods such as biopsy. We aimed to determine whether histogram analysis of hepatobiliary phase images of gadoxetic acid-enhanced magnetic resonance imaging (MRI) can provide non-invasive quantitative measurement of liver fibrosis. METHODS This retrospective stu...